Effects of gum treatment on inflammation markers in children with gingivitis
The Effects of Periodontal Therapy on Gingival Crevicular Fluid NLRP3,Caspase-1,IL-1β Levels in Children With Gingivitis
This study is testing if gum treatment can lower inflammation in children aged 11-14 with gingivitis by checking their gum fluid before and after the treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 11 Years to 14 Years |
| Sex | All |
| Sponsor | Aydin Adnan Menderes University Academic / other |
| Locations | 1 site (Aydin) |
| Trial ID | NCT06507280 on ClinicalTrials.gov |
What this trial studies
This study investigates the levels of inflammation markers NLRP3, caspase-1, and IL-1β in the gingival crevicular fluid of children aged 11-14 with gingivitis. Participants will undergo periodontal therapy, and their fluid samples will be collected before treatment and again on the 7th and 30th days post-treatment to assess changes in these markers. The goal is to understand how effective periodontal treatment is in reducing inflammation associated with gingivitis in pediatric patients.
Who should consider this trial
Good fit: Ideal candidates for this study are systemically healthy children aged 11-14 with permanent dentition who have been diagnosed with gingivitis.
Not a fit: Patients who are systemically unhealthy or require endodontic and restorative treatment will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment protocols for managing gingivitis in children, potentially reducing inflammation and promoting better oral health.
How similar studies have performed: While there have been studies on periodontal therapy in adults, this specific focus on pediatric patients and the measurement of these particular inflammation markers is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Inclusion criteria for the group with gingivitis; * Systemically healthy * 11-14 years old * Permanent dentition * No need for endodontic and restorative treatment * Gingivitis with gingivitis * Have verbally and in writing agreed to participate in the study and are willing to attend follow-up appointments regularly participants will be included in the study. Inclusion criteria for the healthy group; * Systemically healthy * 11-14 years old * Permanent dentition * No need for endodontic and restorative treatment * Periodontally healthy * Have verbally and in writing agreed to participate in the study and are willing to attend follow-up appointments regularly participants will be included in the study. Exclusion Criteria * In need of endodontic and restorative treatment * Systemically unhealthy * Patients who do not give verbal or written consent
Where this trial is running
Aydin
- Sultan Keles — Aydin, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Sultan Keleş, Assoc.Prof.
- Email: dtsultank@gmail.com
- Phone: 05318438557
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.