Effects of glucocorticoids on fat mass during overeating in overweight individuals
Official title: Acute Consequences of Glucocorticoid Secretion in Overweight and Obese Individuals During Maximum Calorie Intake: a Double-blind, Randomized, Placebo-controlled, Cross-over Study
Run by University Hospital, Basel, Switzerland · NCT06556277 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing if a treatment that mimics natural hormone patterns can help overweight people manage fat gain when they eat too much.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | Men only |
| Enrollment | 23 (estimated) |
| Sponsor | University Hospital, Basel, Switzerland Academic / other |
| Locations | 1 site (Basel, Basel-Stadt) |
| Trial ID | NCT06556277 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are males aged 18 to 50 years with a BMI of 25 kg/m² or higher and stable weight for the past three months.
✕Probably not a fit
Patients with severe chronic diseases, diabetes, or those on certain medications may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates how food-induced glucocorticoids affect fat mass in overweight and obese individuals during periods of excessive calorie intake. In a randomized, cross-over design, 23 participants will receive either a treatment that mimics natural glucocorticoid rhythms or a placebo while undergoing two identical overfeeding phases. The treatment involves administering metyrapone and hydrocortisone to suppress glucocorticoid peaks induced by food intake. The study aims to compare metabolic, autonomic, and immunological parameters to understand the role of glucocorticoids in obesity.
Why it matters
Potential benefit: If successful, this study could lead to new therapeutic strategies for managing obesity by targeting glucocorticoid levels.
How similar studies have gone: While the role of glucocorticoids in obesity has been studied, this specific approach of manipulating glucocorticoid rhythms during overeating is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Males aged 18 to 50 years * BMI≥ 25 kg/m² with a stable weight within past three months before study initiation Exclusion Criteria: * Any severe acute or chronic disease, including diabetes mellitus type 2 * Intake of GLP-1 agonists or hormone therapy * Hypercortisolism * Casual smoking (more than 6 cigarettes per day) * Frequent, heavy alcohol consumption (more than 30g/day) * Frequent, heavy caffeine consumption (more than 4 caffeinated drinks/day) * Regular physical exercise (more than 4hrs per week) * Shift work * Participation in an investigational drug trial within the past two months * Intake of any steroid-containing drugs, including topical steroids and inhalers, within 4 weeks of the study initiation * Known allergy to metyrapone * Inability or unwillingness to provide informed consent
Where it's running
-
University Hospital Basel
Basel, Basel-Stadt, Switzerland Recruiting
Study contacts
- Principal investigator: Eleonora Seelig, PD Dr.med. — Sponsor and principal investigator
- Study coordinator: Eleonora Seelig, PD Dr.med.
- Email: eleonora.seelig@usb.ch
- Phone: 0041 61 328 63 23
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.