Effects of gene variations on endurance performance after caffeine intake
Effects of Caffeine, CYP1A2 and ADORA2A Genotypes on Cycling Endurance Performance.
This study is testing how different gene variations affect how well young adults perform in endurance activities after taking caffeine.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 35 Years |
| Sex | All |
| Sponsor | Masaryk University Academic / other |
| Locations | 1 site (Brno) |
| Trial ID | NCT06547307 on ClinicalTrials.gov |
What this trial studies
This randomized, double-blind, placebo-controlled study aims to evaluate how specific gene polymorphisms (CYP1A2 and ADORA2A) influence endurance performance following caffeine consumption. The study will involve 60 healthy participants aged 18-35, who will undergo a series of tests over four weeks while adhering to specific dietary and activity guidelines. Participants will be administered varying doses of caffeine to assess its ergogenic effects based on their genetic makeup. The study will take place at the Faculty of Sports Studies of Masaryk University, ensuring controlled conditions to minimize external influences on performance.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy individuals aged 18-35 with no contraindications to caffeine intake.
Not a fit: Patients with cardiovascular disease, hypertension, or liver disease, as well as pregnant or breastfeeding individuals, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help tailor caffeine consumption strategies to enhance athletic performance based on individual genetic profiles.
How similar studies have performed: Previous studies have explored the relationship between genetics and caffeine's effects on performance, indicating potential for success in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * healthy person * any training status * within age limits * without contraindications to perform the test on a bicycle trainer * No contraindications to caffeine intake Exclusion Criteria: * Pregnancy * Breast feeding * Cardiovascular disease * Hypertension * Liver disease in the previous two months * Taking drugs that can affect liver function * Illness in the period of 14 days before the start of the research * Use of caffeine during research
Where this trial is running
Brno
- Masaryk University — Brno, Czechia (Recruiting)
Study contacts
- Principal investigator: Lucie Lipková — Masaryk University
- Study coordinator: Dominik Puda
- Email: dominik.puda@fsps.muni.cz
- Phone: +420724587249
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.