Effects of fish oil on brown fat activation during cold exposure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates whether fish oil supplementation can enhance the activation of brown adipose tissue and improve thermoregulation during cold exposure. It is a randomized, double-blind, placebo-controlled study involving 30 healthy participants aged 18-40, who will receive either fish oil or a placebo for 12 weeks. The study will assess various thermoregulatory responses, including core body temperature, shivering, and skin blood flow, through a controlled cold exposure protocol. This innovative approach aims to provide a comprehensive understanding of how fish oil may influence the body's response to cold environments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male and female, between the ages of 18 to 40 years.
* Body Mass Index (BMI) of 18.5 to 24.9 kg/m2
* Considered "moderately to highly active" by the International Physical Activity Questionnaire (IPAQ) and the Physical Activity Readiness Questionnaire (PAR-Q+)

Exclusion Criteria:

* History of smoking or recreational smoking, hyperlipidemia, hypertension/cardiovascular disease, diabetes, renal disease, neurological disease, metabolic disease, and bleeding disorders or delayed clotting time.
* Taking SSRI's (antidepressants and anxiety medication), ADD/ADHD medication, and chronically consume pain medication (Aleve, Tylenol, CBD, etc).
* Have or have had chronic disorders of the rectum (e.g., cancer, surgery, active hemorrhoids, etc.) or who currently have related acute conditions (diarrhea, constipation, etc.).
* Have or have had a diagnosis of disorders related to immune suppression and/or autoimmune disease.
* Are pregnant or planning on being pregnant.
* Resting blood pressure of \> 130mmHg systolic or 90 mmHg diastolic.
* Resting Pulse rate of \> 100 bpm.
* History of regularly consuming fish oil supplements and/or regularly eating more than one fish meal per week.
* Consuming more than one fish meal per week during the study.

Where it's running

• Human Perfromance Lab, Indiana University
  Bloomington, Indiana, United States Recruiting

Study contacts

• Principal investigator: Timothy D Mickleborough, PhD — Indiana University
• Study coordinator: Timothy D Mickleborough, PhD
• Email: tmickleb@indiana.edu
• Phone: 812-855-0753

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.