Effects of fish oil on brown fat activation during cold exposure
Omega-3 Fatty Acid Modulation of Brown Adipose Tissue for Arctic Resilience
NA · Indiana University · NCT05822141
This study is testing if taking fish oil can help healthy young adults better activate their brown fat and stay warm when exposed to cold temperatures.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Sponsor | Indiana University (other) |
| Locations | 1 site (Bloomington, Indiana) |
| Trial ID | NCT05822141 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates whether fish oil supplementation can enhance the activation of brown adipose tissue and improve thermoregulation during cold exposure. It is a randomized, double-blind, placebo-controlled study involving 30 healthy participants aged 18-40, who will receive either fish oil or a placebo for 12 weeks. The study will assess various thermoregulatory responses, including core body temperature, shivering, and skin blood flow, through a controlled cold exposure protocol. This innovative approach aims to provide a comprehensive understanding of how fish oil may influence the body's response to cold environments.
Who should consider this trial
Good fit: Ideal candidates are healthy men and women aged 18-40 with a BMI between 18.5 and 24.9 who are moderately to highly active.
Not a fit: Patients with a history of cardiovascular disease, metabolic disorders, or those taking certain medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new dietary recommendations for improving thermal comfort and metabolic health during cold exposure.
How similar studies have performed: While the specific approach of using fish oil for brown fat activation during cold exposure is novel, related studies on dietary fats and thermoregulation have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male and female, between the ages of 18 to 40 years. * Body Mass Index (BMI) of 18.5 to 24.9 kg/m2 * Considered "moderately to highly active" by the International Physical Activity Questionnaire (IPAQ) and the Physical Activity Readiness Questionnaire (PAR-Q+) Exclusion Criteria: * History of smoking or recreational smoking, hyperlipidemia, hypertension/cardiovascular disease, diabetes, renal disease, neurological disease, metabolic disease, and bleeding disorders or delayed clotting time. * Taking SSRI's (antidepressants and anxiety medication), ADD/ADHD medication, and chronically consume pain medication (Aleve, Tylenol, CBD, etc). * Have or have had chronic disorders of the rectum (e.g., cancer, surgery, active hemorrhoids, etc.) or who currently have related acute conditions (diarrhea, constipation, etc.). * Have or have had a diagnosis of disorders related to immune suppression and/or autoimmune disease. * Are pregnant or planning on being pregnant. * Resting blood pressure of \> 130mmHg systolic or 90 mmHg diastolic. * Resting Pulse rate of \> 100 bpm. * History of regularly consuming fish oil supplements and/or regularly eating more than one fish meal per week. * Consuming more than one fish meal per week during the study.
Where this trial is running
Bloomington, Indiana
- Human Perfromance Lab, Indiana University — Bloomington, Indiana, United States (RECRUITING)
Study contacts
- Principal investigator: Timothy D Mickleborough, PhD — Indiana University
- Study coordinator: Timothy D Mickleborough, PhD
- Email: tmickleb@indiana.edu
- Phone: 812-855-0753
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cold Exposure, Brown fat, Fish oil, Cold