Effects of extreme heat on heart blood flow in young and older adults
Impact of Extreme Heat on Myocardial Blood Flow and Flow Reserve in Young and Older Adults
This study tests how extreme heat affects blood flow to the heart in both young and older adults to see if older people are at greater risk during hot weather.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 24 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Texas Southwestern Medical Center Academic / other |
| Locations | 1 site (Dallas, Texas) |
| Trial ID | NCT06842784 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how extreme heat affects myocardial blood flow and flow reserve in both young and older adults. It aims to determine if older adults have reduced myocardial flow reserve compared to younger individuals during heat stress. The study will assess the impact of ambient heat exposure on cardiovascular health, particularly focusing on the risk of myocardial ischemia in older adults. By understanding these effects, the research seeks to highlight the increased cardiovascular risks associated with heat exposure in different age groups.
Who should consider this trial
Good fit: Ideal candidates include healthy individuals aged 18-35 or 65 and older without serious underlying medical conditions.
Not a fit: Patients with known heart disease or chronic medical conditions requiring regular therapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into preventing heat-related cardiovascular events, particularly in older adults.
How similar studies have performed: While there is limited research specifically on myocardial blood flow during heat stress, studies on heat effects on cardiovascular health suggest potential risks, indicating this area is underexplored.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy male and female individuals * 18-35 years or 65+ years of age * Free of any underlying moderate to serious medical conditions Exclusion Criteria: * Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia. * Taking of any medications (such as beta blockers and non-dihydropyridine calcium channel blockers) that have known influences on either cardiac function or sweating responses. * Abnormalities detected on routine screening. * Current smokers, as well as individuals who regularly smoked within the past 3 years. * Body mass index of greater than 30 kg/m\^2 * Pregnant individuals
Where this trial is running
Dallas, Texas
- Texas Health Presbyterian Hospital Dallas — Dallas, Texas, United States (Recruiting)
Study contacts
- Study coordinator: Zachary McKenna, PhD
- Email: ZacharyMckenna@texashealth.org
- Phone: 214-345-6557
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.