Effects of exercise on multiple sclerosis symptoms and function
Evaluating Task-Oriented Exercise Effects on Walking Function and the Central Nervous System in People With Multiple Sclerosis
NA · University of Regina · NCT05496881
This study is testing how different exercise programs can help people with multiple sclerosis feel better and improve their physical abilities.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 69 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Regina (other) |
| Locations | 1 site (Regina, Saskatchewan) |
| Trial ID | NCT05496881 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates how different exercise protocols impact physical function, fitness, and central nervous system function in individuals with multiple sclerosis (MS). A total of 69 participants with moderate motor disability will be randomly assigned to one of three distinct exercise programs, each delivered three times a week for 12 weeks. The study aims to assess the immediate and lasting effects of these exercise interventions on MS symptoms and overall health. The findings could provide valuable insights into optimizing exercise regimens for MS patients.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with progressive multiple sclerosis who have moderate motor disability.
Not a fit: Patients with high levels of physical activity or those with contraindications to exercise may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved exercise recommendations that enhance symptom management and physical function for people living with multiple sclerosis.
How similar studies have performed: Other studies have shown positive outcomes with exercise interventions in MS, but this trial uniquely compares different exercise types on central nervous system effects.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * diagnosis of progressive MS by a neurologist * physician clearance for exercise * a Patient-Determined Disease Steps (PDSS) score between 3 and 7 (i.e., moderate motor disability) * a Timed 25-Foot Walk (T25-FW) test time \> 6.0 s. Exclusion Criteria: * a baseline score \>24 on the Godin-Shephard Leisure Time Physical Activity Questionnaire (i.e., high physical activity levels) * absolute contraindications to TMS (e.g. history of seizure) * a history of any neurological conditions other than MS * relapse in the past three months (self-reported, neurologist confirmed) * psychiatric diagnosis * substance abuse
Where this trial is running
Regina, Saskatchewan
- University of Regina — Regina, Saskatchewan, Canada (RECRUITING)
Study contacts
- Principal investigator: Cameron Mang, PhD — University of Regina
- Study coordinator: Cameron Mang, PhD
- Email: cameron.mang@uregina.ca
- Phone: 306-585-4066
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Secondary Progressive, Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Progressive Multiple Sclerosis, Relapsing-Remitting Multiple Sclerosis, Central Nervous System