Effects of exercise on heart failure with preserved ejection fraction in veterans
Efficacy of Exercise Training in Patients With HFpEF
This study is testing if regular exercise can help veterans with heart failure feel better and improve their ability to exercise by looking at how certain nerves in their muscles affect fatigue.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 21 Years to 85 Years |
| Sex | All |
| Sponsor | VA Office of Research and Development Federal |
| Locations | 1 site (Salt Lake City, Utah) |
| Trial ID | NCT04506606 on ClinicalTrials.gov |
What this trial studies
This research focuses on veterans suffering from heart failure with preserved ejection fraction (HFpEF) to understand the mechanisms behind their exercise intolerance and the potential benefits of regular physical activity. The study will investigate the role of specific nerves in limb muscles that may contribute to fatigue and exercise limitations. By employing a chronic exercise intervention and using lumbar intrathecal fentanyl to block certain muscle afferents, the researchers aim to evaluate how these factors affect exercise tolerance and overall quality of life. The findings could provide insights into alternative treatment strategies for improving symptoms in this patient population.
Who should consider this trial
Good fit: Ideal candidates for this study are veterans diagnosed with heart failure with preserved ejection fraction.
Not a fit: Patients with heart failure with reduced ejection fraction will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved exercise tolerance and quality of life for veterans with HFpEF.
How similar studies have performed: Other studies have shown promise in using exercise interventions for heart failure patients, but this specific approach focusing on muscle afferents is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * heart failure with preserved ejection fraction Exclusion Criteria: * heart failure with reduced ejection fraction
Where this trial is running
Salt Lake City, Utah
- VA Salt Lake City Health Care System, Salt Lake City, UT — Salt Lake City, Utah, United States (Recruiting)
Study contacts
- Principal investigator: Markus Amann, PhD — VA Salt Lake City Health Care System, Salt Lake City, UT
- Study coordinator: Misti R Seppi, MBA BS AAS
- Email: Misti.Seppi@va.gov
- Phone: (801) 582-1565
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.