Effects of Exercise on Fat Metabolism in Postmenopausal Women
Resistance Training Modulation of Fat Metabolism in Obese Postmenopausal Women
This study tests whether resistance training or endurance training helps postmenopausal women who are obese and prediabetic improve their fat metabolism over 12 weeks.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 50 Years to 75 Years |
| Sex | Female |
| Sponsor | Florida State University Academic / other |
| Locations | 1 site (Tallahassee, Florida) |
| Trial ID | NCT05351476 on ClinicalTrials.gov |
What this trial studies
This study investigates how resistance training compares to endurance training in improving fat metabolism among postmenopausal women who are obese and prediabetic. Over 12 weeks, participants will engage in either resistance or endurance exercises while their fat breakdown and synthesis responses are measured through various techniques, including microdialysis. The study aims to provide insights into the potential of resistance exercise as a practical approach to prevent type 2 diabetes in this population.
Who should consider this trial
Good fit: Ideal candidates are sedentary postmenopausal women aged 50-75 with obesity and prediabetes.
Not a fit: Patients with type 1 or type 2 diabetes or those currently engaged in regular exercise may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could offer a new exercise-based strategy to help prevent type 2 diabetes in postmenopausal women.
How similar studies have performed: Other studies have shown positive outcomes with exercise interventions in similar populations, suggesting this approach has potential.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women * Postmenopausal (50-75 yrs.) * Obese (BMI 30-50 kg/m2) * Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg/dL, or 2hr OGTT blood glucose 140 to 199 mg/dL) * Sedentary (not performing purposeful exercise training more than 20 minutes per day twice a week) * Non-smokers * No hormone replacement therapy for at least the past two years. Exclusion Criteria: * Engaging in purposeful resistance training or endurance training (\> 20min/day, \> 2 days/week) * Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic * Type 1 or type 2 diabetes * Medical problems in which exercise is contraindicated, such as chronic infections * History of, or currently presentation with, cancer, cardiovascular or respiratory disease * Uncontrolled thyroid dysfunction, liver or renal dysfunction * Taking any medication affecting lipid metabolism * Musculoskeletal disease or injury that would otherwise prevent engagement in resistance and endurance training * Smokers and those with diagnosed eating disorders
Where this trial is running
Tallahassee, Florida
- Florida State University — Tallahassee, Florida, United States (Recruiting)
Study contacts
- Principal investigator: Robert C Hickner, PhD — Florida State University
- Study coordinator: Robert C Hickner, PhD
- Email: rhickner@fsu.edu
- Phone: 850-644-1375
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.