Effects of Exercise on Fat Metabolism in Postmenopausal Women

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how resistance training compares to endurance training in improving fat metabolism among postmenopausal women who are obese and prediabetic. Over 12 weeks, participants will engage in either resistance or endurance exercises while their fat breakdown and synthesis responses are measured through various techniques, including microdialysis. The study aims to provide insights into the potential of resistance exercise as a practical approach to prevent type 2 diabetes in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women
* Postmenopausal (50-75 yrs.)
* Obese (BMI 30-50 kg/m2)
* Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg/dL, or 2hr OGTT blood glucose 140 to 199 mg/dL)
* Sedentary (not performing purposeful exercise training more than 20 minutes per day twice a week)
* Non-smokers
* No hormone replacement therapy for at least the past two years.

Exclusion Criteria:

* Engaging in purposeful resistance training or endurance training (\> 20min/day, \> 2 days/week)
* Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic
* Type 1 or type 2 diabetes
* Medical problems in which exercise is contraindicated, such as chronic infections
* History of, or currently presentation with, cancer, cardiovascular or respiratory disease
* Uncontrolled thyroid dysfunction, liver or renal dysfunction
* Taking any medication affecting lipid metabolism
* Musculoskeletal disease or injury that would otherwise prevent engagement in resistance and endurance training
* Smokers and those with diagnosed eating disorders

Where it's running

• Florida State University
  Tallahassee, Florida, United States Recruiting

Study contacts

• Principal investigator: Robert C Hickner, PhD — Florida State University
• Study coordinator: Robert C Hickner, PhD
• Email: rhickner@fsu.edu
• Phone: 850-644-1375

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.