Effects of exercise on cardiovascular responses in people living with HIV/AIDS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates how regular exercise impacts cardiovascular responses in individuals living with HIV/AIDS who experience exercise intolerance. Participants will be randomly assigned to either an exercise training group, which will engage in moderate-intensity physical activity three times a week for 12 weeks, or a control group that remains inactive. The study aims to measure changes in blood pressure and autonomic responses during specific tests to assess the effects of exercise on muscle ergoreflex activation. Additionally, a comparison group of inactive HIV-uninfected individuals will be included to provide further insights.

Why it matters

Who can join: the full rules

Inclusion Criteria for people living with HIV:

* diagnosis of HIv infection for at least 5 years;
* use of combined antiretroviral therapy for at least 3 years;
* asymptomatic and free from opportunistic diseases at enrollment.

Exclusion Criteria:

* regular physical exercise;
* malnutrition;
* presence of coronary artery disease, ischemic diseases, pulmonary disease, diabetes, Chagas disease, tuberculosis, heart failure, hypertension;
* using pacemakers and/or antidepressant, antiarrhythmic or antihypertensive medication, especially beta-blockers.

Where it's running

• Rio de Janeiro State University
  Rio de Janeiro, Rio de Janeiro, Brazil Recruiting

Study contacts

• Principal investigator: Julana P Borges, Dr — Rio de Janeiro State University
• Study coordinator: Juliana P Borges, Dr.
• Email: julipborges@gmail.com
• Phone: +552123340775

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.