Effects of eating oranges on liver health in people with fatty liver disease
Evaluation of the Effects of Orange Consumption on Carbohydrate and Lipid Metabolism in Subjects With MAFLD (Metabolic Associated Fatty Liver Disease)
This study tests whether eating oranges can help improve liver health in people with fatty liver disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 30 Years to 65 Years |
| Sex | All |
| Sponsor | Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis Academic / other |
| Locations | 1 site (Castellana Grotte, Bari) |
| Trial ID | NCT05558592 on ClinicalTrials.gov |
What this trial studies
This study evaluates how consuming oranges may influence carbohydrate and lipid metabolism in individuals diagnosed with Metabolic Associated Fatty Liver Disease (MAFLD). Participants will be divided into two groups: one will receive dietary supplementation with fresh oranges, while the other will follow a balanced diet without oranges. The aim is to assess whether the polyphenols in oranges can improve metabolic profiles and reduce risks associated with MAFLD. The study seeks to identify dietary factors that can help prevent or mitigate metabolic diseases.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 30 to 65 years who have been diagnosed with MAFLD.
Not a fit: Patients with gastroesophageal reflux diseases, inflammatory bowel diseases, oncological diseases, or those on special diets or anticoagulants may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into dietary interventions that improve liver health and metabolic profiles in patients with MAFLD.
How similar studies have performed: While there is evidence supporting the health benefits of polyphenols in fruits, this specific approach to using oranges for MAFLD is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * age \> 30 years and \<65 years * diagnosis of MAFLD on the basis of clinical and instrumental parameters Exclusion Criteria: * gastroesophageal reflux diseases; * inflammatory bowel diseases; oncological diseases; * serious medical conditions that may impair participation in the trial; * people who follow a special diet or who use anticoagulants; * subjects unable to follow a diet for religious or other reasons.
Where this trial is running
Castellana Grotte, Bari
- IRCCS Saverio de Bellis — Castellana Grotte, Bari, Italy (Recruiting)
Study contacts
- Study coordinator: Maria Notarnicola, DSc
- Email: maria.notarnicola@irccsdebellis.it
- Phone: 0804994342
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.