Effects of Eating Eggs on Eczema in Singaporeans

Impact of Regular Consumption of Eggs and Nutrients Fortified Eggs on Eczema Condition in Singapore Individuals With Eczema

This study is testing if eating regular or nutrient-fortified eggs every day can help improve eczema symptoms in Singaporeans aged 21 to 59.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 44 (estimated)
• Ages: 21 Years to 59 Years
• Sex: All
• Sponsor: National University of Singapore (other)
• Locations: 1 site (Singapore)
• Trial ID: NCT06454942 on ClinicalTrials.gov

What this trial studies

This study investigates how daily consumption of regular and nutrients-fortified eggs affects eczema in individuals aged 21 to 59 in Singapore. Participants will be randomly assigned to consume either type of egg for 12 weeks while their skin and eye health, along with various biomarkers, will be monitored. The study aims to determine if nutrient-fortified eggs provide additional benefits over regular eggs in improving eczema symptoms. It employs a double-blind, randomized, parallel design to ensure unbiased results.

Who should consider this trial

Good fit: Ideal candidates are healthy adults aged 21 to 59 with mild to moderate eczema and a BMI between 18.5-25 kg/m2.

Not a fit: Patients with significant food allergies to eggs or those on medications that may interfere with the study results may not benefit.

Why it matters

Potential benefit: If successful, this study could lead to dietary recommendations that improve eczema management for patients.

How similar studies have performed: While dietary interventions for eczema have been explored, this specific approach using nutrient-fortified eggs is relatively novel.

Eligibility criteria

Inclusion Criteria:

1. English-literate and able to give informed consent in English
2. Male and female participants, aged between 21 and 59 inclusive
3. Healthy individuals with no underlying condition or on regular medication
4. BMI between 18.5-25 kg/m2
5. Mild to moderate severity of eczema, which will also be determined using our questionnaires during the screening visit

Exclusion Criteria:

1. Significant change in body weight (3 kg or more) in the past 3 months
2. Significant exercise pattern over the past 3 months defined as high-intensity exercise of more than 3 hours per week
3. Known food allergy to eggs
4. Taking dietary supplements which may impact the study results
5. Having gastrointestinal disorders not suitable for the study
6. Current smokers
7. Consumes more than 2 alcoholic drinks per day i.e. one drink is defined as either 150ml of wine, 340ml of beer/cider, or 45ml of distilled spirit
8. Taking lipid-lowering and blood pressure-controlling medications for less than 3 years
9. Pregnant or lactating women, or planning to conceive in the next 6 months
10. Unwilling to stop the medication of eczema during the study, either topical creams or oral medications
11. Hierarchical link (professional and familial ties) with the research team members
12. Participating in another clinical study
13. Having blindness in one eye or more, eye diseases, retinal/lens/optical nerve surgery, or other eye conditions that may impact the study results
14. Low-quality macular pigment optical density results were determined during the screening visit.

Where this trial is running

Singapore

• Department of Food Science and Techonology, Block S13 — Singapore, Singapore (RECRUITING)

Study contacts

• Principal investigator: Jung Eun Kim, PhD, RD — National University of Singapore
• Study coordinator: Yuxin LIANG

Conditions: Atopic Dermatitis Eczema, Aging, Diet Modification, Atopic Dermatitis, Eczema, Young and Middle-aged adults, Eye health, Antioxidants