Effects of dobutamine on heart function in patients with a specific type of heart disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the hemodynamic effects of dobutamine infusion in patients with wild-type Transthyretin Amyloid Cardiomyopathy (ATTRwt). Participants aged 65 and older with symptomatic ATTRwt will receive increasing dosages of dobutamine, and its impact on cardiac output and filling pressures will be assessed using both non-invasive echocardiography and invasive right heart catheterization. The study aims to determine the safety and efficacy of dobutamine in improving heart function in this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. ATTRwt, diagnosis confirmed by genetic testing, 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scintigraphy and/or endomyocardial biopsy.
2. Treated with loop diuretics.
3. New York Heart Association class II-IV.
4. Age ≥ 65 years.
5. Left ventricular ejection fraction (LVEF) \< 50 % and/or SVI assessed by echocardiography \< 35 ml/m2.
6. Thorough oral and written informed consent to participate in the study.

Exclusion Criteria:

1. Moderate to severe aortic stenosis (participants with aortic sclerosis will not be excluded).
2. Other significant valvular diseases.
3. Known severe coronary artery diseases: left main stem stenosis or 3-vessel disease, or recent acute myocardial infarction (\< 4 weeks).
4. Contraindications to the use of dobutamine: Known allergy to dobutamine or sulfite, phaeochromocytoma or ventricular tachycardia (VT).
5. End stage renal disease (eGFR of less than 15 mL/min/1,73 m2).

Where it's running

• Department of Cardiology, Aarhus University Hospital
  Aarhus, Denmark Recruiting

Study contacts

• Study coordinator: Ali Hussein Jaber Mejren, MD
• Email: alimej@clin.au.dk
• Phone: 0045 91 65 18 48

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Understanding Atrioventricular Regurgitation in ATTR Amyloid Cardiomyopathy

  This study is trying to understand how common certain heart valve problems are in people with ATTR amyloid cardiomyopathy and create better ways to measure their severity.

  Recruiting at 8 sites Medical University of Vienna · Graz, Styria and 7 other locations · NCT06836011

• Diagnosing ATTR Cardiac Amyloidosis in Patients with Carpal Tunnel Syndrome

  This study is testing if patients with carpal tunnel syndrome might also have a heart condition called ATTR amyloidosis by doing tests and following them for 10 years.

  Recruiting Helse Møre og Romsdal HF · Ålesund, Møre og Romsdal · NCT06458374

• Evaluation of heart health in patients with ATTR amyloidosis on tafamidis treatment

  This study looks at how tafamidis treatment affects heart health in patients with ATTR amyloidosis by checking their heart rhythm and other health needs every six months.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia · NCT06251778

• Identifying cardiac amyloidosis in older adults with lumbar spinal stenosis

  This study is trying to find out if older adults who have had surgery for lumbar spinal stenosis also have a heart condition called transthyretin cardiac amyloidosis by looking at their spinal tissue and using advanced technology.

  Recruiting at 5 sites Columbia University · Beverly Hills, California and 5 other locations · NCT06034405

• Using tiny blood particles to detect and track ATTR heart amyloidosis

  This project will test whether tiny blood particles called extracellular vesicles can help detect and track transthyretin (ATTR) amyloid cardiomyopathy in people with or at risk for ATTR.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT07314268

• Characterizing wild-type transthyretin amyloidosis cardiomyopathy and its impact on quality of life

  This study is trying to understand how wild-type transthyretin amyloidosis cardiomyopathy affects the quality of life for patients at different stages of the disease compared to healthy individuals.

  Recruiting Aarhus University Hospital Skejby · Aarhus, Arrhus N · NCT06291805

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.