Effects of Different Cannabis Strains on Perception, Feelings, and Performance

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a Phase 1, double-blind, placebo-controlled laboratory study where participants will complete six outpatient sessions. In each session, they will self-administer smoked cannabis labeled as indica, sativa, or generic, at 0 mg or 25 mg THC, in a within-subjects design. Primary outcomes include cognitive and psychomotor performance, subjective effects, and simulated driving performance, along with smoking topography. The trial aims to characterize how different labelings and THC levels influence use outcomes in healthy, adult cannabis users.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Have provided written informed consent.
* Be between the ages of 21 and 55
* Be in good general health based on a physical examination, medical history, vital signs, and screening urine and blood tests
* Test negative for drugs of abuse including breath alcohol at the screening visit and at clinic admission
* Not be pregnant or nursing (if female). All females must have a negative serum pregnancy test at the screening visit and a negative urine pregnancy test at clinic admission. Participants must confirm use of appropriate birth control methods (e.g., condoms, birth control pills) throughout the entirety of the study.
* Blood pressure at Screening Visit does not exceed a systolic blood pressure (SBP) of 150 mmHg or a diastolic blood pressure (DBP) of 90 mmHg
* Have prior experience smoking cannabis but not currently using more than 3 times per week on average; participants must be active cannabis users (i.e., report past 3-month use) to participate.

Exclusion Criteria:

* Self-reported use of illicit drugs (e.g., amphetamine, cocaine, methamphetamine, 3,4-Methylenedioxymethamphetamine (MDMA), lysergic acid diethylamide (LSD), ketamine, heroin, psilocybin, prescription medications not prescribed to the person) in the past 30 days.
* History of or current evidence of significant medical (e.g., seizure disorder) or psychiatric illness (e.g. psychosis) judged by the investigator to put the participant at greater risk of experiencing an adverse event due to exposure or completion of other study procedures.
* History of clinically significant cardiac arrhythmias or vasospastic disease (e.g., Prinzmetal's angina).
* Enrolled in another clinical trial or having received any drug as part of a research study within 30 days prior to dosing.
* Having previously sought medical attention to manage adverse effects following acute cannabis use
* Individuals with anemia or who have donated blood in the prior 30 days

Where it's running

• Johns Hopkins University
  Baltimore, Maryland, United States Recruiting

Study contacts

• Principal investigator: Carlos A Zamarripa, PhD — Johns Hopkins University
• Study coordinator: Carlos A Zamarripa, PhD
• Email: czamarr2@jhmi.edu
• Phone: 410-550-6969

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Effects of vaporized cannabis and alcohol on impairment

  This study is testing how using alcohol and vaporized cannabis together affects people's ability to think and act, to help understand the risks of mixing these substances.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.