Effects of different anesthetics on brain connectivity
The Effects of Different Anesthetics on Functional Connectivity in Volunteers and Patients With Brain Tumor (ACTION)
This study is testing how different sedatives affect brain connections in healthy people and brain tumor patients during scans.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 240 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | Male |
| Sponsor | Beijing Tiantan Hospital Academic / other |
| Locations | 1 site (Beijing) |
| Trial ID | NCT03343873 on ClinicalTrials.gov |
What this trial studies
This research investigates how various sedatives, specifically midazolam, dexmedetomidine, and propofol, influence brain functional connectivity in both healthy volunteers and brain tumor patients. The study will involve 240 participants who will undergo resting and task fMRI scans at different sedation levels, ranging from awake to deep sedation. The primary focus is to assess the impact of sedation on brain network connections, while secondary outcomes will evaluate the effects on specific brain networks and monitor vital parameters and adverse events.
Who should consider this trial
Good fit: Ideal candidates include healthy male volunteers and male brain tumor patients aged 18 to 65 who can provide informed consent.
Not a fit: Patients with significant systemic complications, a history of major surgical anesthesia, or contraindications for MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of sedation effects on brain function, potentially leading to improved anesthetic practices.
How similar studies have performed: While studies on anesthetic effects exist, this specific investigation into functional connectivity with a focus on different sedation levels is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 1\. Male, 18 \~ 65 years old * 2\. Healthy Volunteer / Brain Tumor Patients * 3\. Senior high school and above * 4\. Sign informed consent Exclusion Criteria: * 1\. In vivo implant MRI check taboo * 2\. Cardiopulmonary liver and kidney and other systemic complications * 3\. History of major surgical anesthesia * 4\. Abuse of drugs, alcoholism history * 5\. Test drug allergy history * 6\. Claustrophobia * 7\. Left hand
Where this trial is running
Beijing
- Beijing Tian Tan Hospital — Beijing, China (Recruiting)
Study contacts
- Study coordinator: Ruquan Han, M.D., Ph.D
- Email: ruquan.han@gmail.com
- Phone: 8610-67096660
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.