Effects of dietary nitrate supplements on oral health
Evaluating the Impact of Various Dietary Nitrate Supplementation Forms on Microbiological Markers of Oral Health and Acceptability Among Adult Participants
NA · Newcastle University · NCT06956612
This study tests if taking beetroot juice or beetroot crystals can improve oral health for healthy adults by looking at things like saliva and mouth bacteria.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Newcastle University (other) |
| Locations | 1 site (Newcastle) |
| Trial ID | NCT06956612 on ClinicalTrials.gov |
What this trial studies
This study investigates how different dietary nitrate supplements, specifically beetroot juice and freeze-dried beetroot crystals, impact oral health markers such as salivary pH and oral microbiome composition in healthy adults aged 18-65. Participants will be randomly assigned to one of three groups: a control group receiving a placebo, a group consuming beetroot juice standardized to contain approximately 400 mg of nitrate, and a group taking freeze-dried beetroot crystals. The study also aims to assess the acceptability and ease of integrating these supplements into daily diets.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy adults aged 18 to 65 years without chronic diseases or conditions affecting oral health.
Not a fit: Patients with chronic diseases, current smokers, or those with dietary restrictions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new dietary interventions that improve oral health and microbiome balance.
How similar studies have performed: While the specific approach of using dietary nitrate supplements for oral health is relatively novel, similar studies have shown promising results in other health areas.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy volunteers * Aged 18 - 65 years. Exclusion Criteria: * Aged less than 18 or more than 65 years old. * Current smoking * Alcohol consumption of greater than14 units per week. * Diagnosis of a chronic disease (e.g., cardiovascular disease, diabetes, cancer, or gastrointestinal disorders), including oral diseases. * Use of antibiotics within the past three months or medications/nutritional supplements that may affect the oral cavity (e.g., prebiotics, probiotics, or hormone replacement therapy). * Regular use of antibacterial mouthwash or xylitol-containing products (e.g., gum or toothpaste) or the use of proton pump inhibitors. * Presence of braces/invisalign or dentures. * Known allergy to any food, including beets * Adherence to dietary restrictions (e.g., weight loss diet) * Eating disorders that may limit participation in the study. * Currently pregnant, breastfeeding or trying to become pregnant. * Participation in other studies.
Where this trial is running
Newcastle
- Newcastle University, Newcastle upon Tyne, Tyne and Wear NE2 4HH — Newcastle, United Kingdom (RECRUITING)
Study contacts
- Principal investigator: Oliver Shannon, PhD — Newcastle University
- Study coordinator: Shatha Alhulaefi
- Email: S.Alhulaefi2@newcastle.ac.uk
- Phone: +44783361076
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Oral Health, Dietary Nitrate, Dietary nitrate, oral health, salivary acidity, oral microbiome