Effects of dietary nitrate supplements on oral health
Official title: Evaluating the Impact of Various Dietary Nitrate Supplementation Forms on Microbiological Markers of Oral Health and Acceptability Among Adult Participants
Run by Newcastle University · NCT06956612 · Data updated 2026-11-12
This study tests if taking beetroot juice or beetroot crystals can improve oral health for healthy adults by looking at things like saliva and mouth bacteria.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Newcastle University Academic / other |
| Locations | 1 site (Newcastle) |
| Status | Recruiting |
| Started | May 23, 2025 |
| Main results expected | December 2025 |
| Study ends | April 2026 |
| Registry record updated | May 28, 2025 |
| Trial ID | NCT06956612 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are healthy adults aged 18 to 65 years without chronic diseases or conditions affecting oral health.
✕Probably not a fit
Patients with chronic diseases, current smokers, or those with dietary restrictions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates how different dietary nitrate supplements, specifically beetroot juice and freeze-dried beetroot crystals, impact oral health markers such as salivary pH and oral microbiome composition in healthy adults aged 18-65. Participants will be randomly assigned to one of three groups: a control group receiving a placebo, a group consuming beetroot juice standardized to contain approximately 400 mg of nitrate, and a group taking freeze-dried beetroot crystals. The study also aims to assess the acceptability and ease of integrating these supplements into daily diets.
Why it matters
Potential benefit: If successful, this study could lead to new dietary interventions that improve oral health and microbiome balance.
How similar studies have gone: While the specific approach of using dietary nitrate supplements for oral health is relatively novel, similar studies have shown promising results in other health areas.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy volunteers * Aged 18 - 65 years. Exclusion Criteria: * Aged less than 18 or more than 65 years old. * Current smoking * Alcohol consumption of greater than14 units per week. * Diagnosis of a chronic disease (e.g., cardiovascular disease, diabetes, cancer, or gastrointestinal disorders), including oral diseases. * Use of antibiotics within the past three months or medications/nutritional supplements that may affect the oral cavity (e.g., prebiotics, probiotics, or hormone replacement therapy). * Regular use of antibacterial mouthwash or xylitol-containing products (e.g., gum or toothpaste) or the use of proton pump inhibitors. * Presence of braces/invisalign or dentures. * Known allergy to any food, including beets * Adherence to dietary restrictions (e.g., weight loss diet) * Eating disorders that may limit participation in the study. * Currently pregnant, breastfeeding or trying to become pregnant. * Participation in other studies.
Where it's running
-
Newcastle University, Newcastle upon Tyne, Tyne and Wear NE2 4HH
Newcastle, United Kingdom Recruiting
Study contacts
- Principal investigator: Oliver Shannon, PhD — Newcastle University
- Study coordinator: Shatha Alhulaefi
- Email: S.Alhulaefi2@newcastle.ac.uk
- Phone: +44783361076
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Can mouth health and chewing help explain arterial stiffness in healthy adults
This study tests whether a profile of oral health and function adds information about central arterial stiffness beyond traditional risk factors in healthy adults.
-
Large language models for turning structured dental radiology data into narrative reports
This study tests whether a language model can convert organized dental X‑ray findings into clear, complete radiology reports.
-
Turkish Oral Assessment Sheet for checking mouth health in older adults.
This project will test whether the Turkish version of the Oral Assessment Sheet works well for people aged 60 and older to check lips, tongue, saliva, swallowing, and voice.
-
Oral health knowledge in pregnant women: does a one-time information leaflet help?
A one-time printed leaflet is tested to see if it improves oral health knowledge in pregnant women attending Hospital La Fe.
-
Oral signs to help spot eating disorders early
This project will test whether a standardized checklist of mouth and dental signs can help detect eating disorders in adults aged 18–40 during routine dental visits.
-
Dietary nitrate to limit muscle loss during leg immobilization in young men
This test will see if drinking nitrate-rich beetroot juice prevents muscle loss and metabolic changes during short-term leg immobilization in healthy men aged 18–44.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.