Effects of Dexmedetomidine with Desflurane or Propofol in Lung Surgery

The Anesthesia Effects of Dexmedetomidine Combined With Desflurane or Propofol in Lobectomy.

This study tests whether using dexmedetomidine with either desflurane or propofol can help patients recover faster and have fewer complications after lung surgery.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 120 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: The Second Affiliated Hospital of Chongqing Medical University (Academic / other)
• Locations: 2 sites (Chongqing, Chongqing and 1 other locations)
• Trial ID: NCT06207344 on ClinicalTrials.gov

What this trial studies

This study investigates the effects of dexmedetomidine combined with either desflurane or propofol during one-lung ventilation surgery for lobectomy. It aims to determine which combination leads to faster recovery and fewer postoperative complications, particularly focusing on pulmonary issues and the incidence of delirium and nausea. The study involves patients undergoing elective thoracoscopic unilateral lobectomy, requiring general anesthesia for at least one hour. The goal is to enhance recovery times and minimize complications associated with anesthesia management in lung surgeries.

Who should consider this trial

Good fit: Ideal candidates are adults over 18 years old who are scheduled for elective thoracoscopic unilateral lobectomy and classified as ASA physical condition I-III.

Not a fit: Patients with obesity, severe hypertension, or significant pulmonary or cardiac conditions may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved recovery times and reduced postoperative complications for patients undergoing lobectomy.

How similar studies have performed: Previous studies have indicated that inhalation anesthesia with desflurane may offer advantages over propofol, suggesting potential success for this approach.

Eligibility criteria

Inclusion Criteria:

1. Patients undergoing elective thoracoscopic unilateral lobectomy.
2. General anesthesia is required and the expected duration of one-lung ventilation is ≥ 1h.
3. American Association of Anesthesiologists (ASA) physical condition classification I-III.
4. Patients over 18 years old.
5. Voluntary participation and ability to understand and sign the informed consent.

Exclusion Criteria:

1. Obese patients (BMI\>28 kg/m2).
2. patients with grade 3 hypertension (systolic blood pressure ≥180 mmHg and/or diastolic blood pressure ≥110 mmHg).
3. Acute coronary syndrome, sinus bradycardia (heart rate \< 45 beats/min), II or III degree atrioventricular block, NYHA heart function classification III or IV.
4. Patients with severe history of chronic obstructive pulmonary disease (GOLD grade III or IV of pulmonary function of chronic obstructive pulmonary disease), severe or uncontrolled bronchial asthma, pulmonary infection, bronchiectasis and thoracic deformity.
5. Pulmonary artery pressure ≥60 mmHg.
6. Patients with Child grade B or C of liver function.
7. Patients with chronic kidney disease in stage 4 or 5.
8. Patients with hyperthyroidism and pheochromocytoma.
9. Patients who are expected to need mechanical ventilation after operation.
10. People with hearing, intelligence, communication and cognitive impairment.
11. For any reason, it is impossible to cooperate with the study or the researcher thinks that it is not suitable to be included in this experiment.
12. patients who are expected to be transferred to ICU after operation.

Where this trial is running

Chongqing, Chongqing and 1 other locations

• The Second Affiliated Hospital of Chongqing Medical University — Chongqing, Chongqing, China (Recruiting)
• The Second Affiliated Hospital of Chongqing Medical University — Chongqing, Chongqing, China (Recruiting)

Study contacts

• Principal investigator: Bing Chen — The Second Affiliated Hospital of Chongqing Medical University
• Study coordinator: Yu Chen

Conditions Anesthesia Recovery Period; Postoperative Complications