Effects of CPAP vs. High Flow Nasal Oxygen in ARDS Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the physiological effects of continuous positive airway pressure (CPAP) compared to high flow nasal oxygenation (HFNO) in patients suffering from acute respiratory distress syndrome (ARDS). It is a multicenter, randomized, open-label, controlled trial involving 120 non-intubated patients who will receive either CPAP or HFNO for 48 hours alongside standard intensive care. The primary outcome is the assessment of lung injury through the biomarker sRAGE, while secondary outcomes include various pulmonary dysfunction biomarkers and intubation rates. The study aims to determine if CPAP can effectively reduce lung injury and improve clinical outcomes compared to HFNO.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* PaO2/FiO2 ratio \<300 mmHg with FiO2 \>40% and PEEP ≥5 cmH2O (CPAP) or flow ≥30 L/min (HFNC).
* Bilateral pulmonary opacities observed in the chest X-ray, thoracic computerized tomography (CT) scan or lung ultrasonography (bilateral B lines)
* \<7 days from the pulmonary insult to symptom onset and criteria 1 and 2
* Not meeting the aforementioned criteria for \>24 hours prior to study inclusion.

Exclusion Criteria:

* Age \<18 years or \>80 years
* History of chronic respiratory failure or interstitial pulmonary disease
* Acute cardiogenic pulmonary edema after echocardiographic evaluation
* Having received either invasive mechanical ventilation or non-invasive mechanical ventilation (NIV)
* Atelectasis, pleural effusion, pulmonary masses or nodules as the primary finding in thoracic imaging.
* "Do not intubate, do not resuscitate" orders
* Presenting significant nasal obstruction.

Where it's running

• Hospital Clínic de Barcelona
  Barcelona, Barcelona, Spain Recruiting

Study contacts

• Study coordinator: Ricard Mellado Artigas, PhD
• Email: rmellado@clinic.cat
• Phone: +34 646217716

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Understanding immune patterns and ECMO strategies to help adults with severe ARDS

  This study tests how different immune and clinical patterns in adults with moderate-to-severe ARDS respond to ECMO and lung-protective care, aiming to improve outcomes.

  Recruiting at 16 sites Southeast University, China · Beijing, Beijing Municipality and 38 other locations · NCT07726940

• Optimal corticosteroid dosing for ARDS: short vs. prolonged therapy

  This trial tests different corticosteroid doses and treatment lengths to see which helps adults with ARDS who are on ventilators.

  Recruiting Phase 4 National Taiwan University Hospital · Taipei · NCT07711964

• Lateral positioning to optimize breathing in adults after abdominal surgery with ARDS

  This study tests whether lying on the left or right side helps improve lung function in adults who developed ARDS after abdominal surgery, using a bedside imaging test to watch ventilation and blood flow while changing positions.

  Recruiting Ruijin Hospital · Shanghai · NCT07669558

• Dexamethasone for sepsis-related ARDS in adults on ventilatory support

  This trial tests whether dexamethasone can help adults with sepsis-associated ARDS on ventilators recover better compared to placebo.

  Recruiting Phase 3 Southeast University, China · Nanjing, Jiangsu and 1 other locations · NCT07576660

• NIRS for EDResp: Which first helps hypoxemic adults best?

  This trial tests whether non-invasive ventilation with a mask (NIPPV) or high-flow nasal oxygen (HFNO) is more helpful for adults in the emergency department with acute hypoxemic respiratory failure.

  Recruiting at 9 sites Ohio State University · Tucson, Arizona and 8 other locations · NCT07558265

• Sodium bicarbonate with bedside electrical impedance tomography to map lung blood flow in ventilated adults

  This project will try whether a small sodium bicarbonate injection combined with bedside electrical impedance tomography can map lung blood flow in adults on mechanical ventilation, compared with hypertonic saline.

  Recruiting First Affiliated Hospital of Wannan Medical College · Wuhu, Anhui · NCT07542366

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.