Effects of cooling duration on recovery in cardiac arrest patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter, randomized clinical trial investigates the impact of varying durations of induced hypothermia on neurological outcomes in comatose survivors of out-of-hospital cardiac arrest. The study aims to determine if longer cooling durations correlate with improved recovery rates and to identify the optimal cooling duration for neuroprotection. Participants will be cooled to below 34 degrees Celsius within 240 minutes of cardiac arrest, with careful monitoring and adaptive allocation of treatment based on outcomes. The trial seeks to enhance strategies for improving neurological recovery in this critical patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Coma after resuscitation from out of hospital cardiac arrest
* Cooled to \<34 deg C with 240 minutes of cardiac arrest
* Definitive temperature control applied
* Age ≥ 18 years
* Informed consent from legal authorized representative (LAR) including intent to maintain life support for 96 hours
* Enrollment within 6 hours of initiation of cooling

Exclusion Criteria:

* Hemodynamic instability
* Pre-existing neurological disability or condition that confounds outcome determination
* Pre-existing terminal illness, unlikely to survive to outcome determination
* Planned early withdrawal of life support
* Presumed sepsis as etiology of arrest
* Prisoner

Where it's running

• Banner University Medical Center
  Tucson, Arizona, United States Recruiting
• Cedars-Sinai Medical Center
  Los Angeles, California, United States Recruiting
• Ronald Regan UCLA Medical Center
  Los Angeles, California, United States Recruiting
• UC Davis Medical Center
  Sacramento, California, United States Recruiting
• UC San Diego Medical Center - Hillcrest
  San Diego, California, United States Recruiting
• Zuckerberg San Francisco General Hospital
  San Francisco, California, United States Recruiting

+27 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Principal investigator: William Meurer — University of Michigan
• Study coordinator: William Meurer
• Email: wmeurer@med.umich.edu
• Phone: 734-232-2142

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.