Effects of cold exposure on the cardiovascular system
Acute Effects of Cold Exposure on Cardiovascular System and Potential Mechanism in Healthy Young Adults: A Randomized Controlled Study
This study tests how being in cold temperatures affects the heart and blood vessels in healthy young adults.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 30 Years |
| Sex | All |
| Sponsor | Fudan University Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Trial ID | NCT06652425 on ClinicalTrials.gov |
What this trial studies
This study investigates how exposure to low temperatures affects the cardiovascular system in healthy young adults. Conducted as a randomized controlled crossover trial, participants will experience both low (15°C) and moderate (22°C) temperatures in a controlled environment. Health examinations, including blood pressure tests and Holter monitoring, will be performed before, during, and after exposure. Blood and urine samples will also be collected to analyze physiological responses.
Who should consider this trial
Good fit: Ideal candidates are healthy young adults living in Shanghai, with a body mass index between 18.5 and 28, who can read and understand Chinese.
Not a fit: Patients with existing cardiovascular, respiratory, or chronic diseases, as well as those with a history of major surgeries or neurological disorders, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into how cold exposure impacts cardiovascular health, potentially informing guidelines for individuals in cold environments.
How similar studies have performed: While studies on temperature effects on health exist, this specific approach focusing on acute cardiovascular responses to cold exposure is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Living in Shanghai during the study period; * Body mass index \> 18.5 and ≤ 28; * Right-handed; * Receiving or having received higher education; * With the ability to read and understand Chinese smoothly. Exclusion Criteria: * Smoking and alcohol abuse; * Current drug and dietary supplements intake; * Subjects with allergic diseases, such as allergic rhinitis, allergic asthma, and atopy; * Subjects with cardiovascular diseases, such as congenital heart disease, pulmonary heart disease, and hypertension; * Subjects with respiratory diseases, such as asthma, chronic bronchitis, and chronic obstructive pulmonary disease; * Subjects with chronic diseases, such as diabetes, chronic hepatitis, and kidney disease; * Subjects who have a history of major surgery due to cardiovascular, cerebrovascular, respiratory, or neurological diseases; * Subjects with neurologic disorders, such as stroke, traumatic brain injury, epilepsy, and schizophrenia; * Abnormal spirometry (FEV1 and FVC ≤ 75% of predicted and FEV1/FVC ≤ 0.65); * Subjects with color vision disabilities.
Where this trial is running
Shanghai, Shanghai Municipality
- Department of Environmental Health, School of Public Health, Fudan University — Shanghai, Shanghai Municipality, China (Recruiting)
Study contacts
- Study coordinator: Renjie Chen, PhD
- Email: chenrenjie@fudan.edu.cn
- Phone: +86-021-54237908
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.