Effects of chronic cough on daily activities and exercise response
Impact of Chronic Cough on Activities of Daily Living and Response to Acute High-intensity Exercise
This study looks at how chronic cough affects daily life and exercise in adults with the condition compared to healthy people, and whether high-intensity exercise can help reduce cough symptoms.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 129 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Leeds Academic / other |
| Locations | 1 site (Leeds, West Yorkshire) |
| Trial ID | NCT06766175 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how chronic cough affects daily living activities and physical activity levels in individuals compared to healthy controls. It aims to characterize the impact of chronic cough on physical and psychological well-being, including social isolation and confidence in performing routine tasks. Additionally, the study will assess the short-term effects of high-intensity exercise on cough frequency and severity. Participants will be adults over 18 with chronic cough lasting more than eight weeks and a high symptom burden.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 with chronic cough lasting more than eight weeks and significant symptom burden.
Not a fit: Patients with recent respiratory infections, smokers, or those with long-COVID may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into managing chronic cough and improving the quality of life for affected patients.
How similar studies have performed: While chronic cough is a common condition, this specific approach to assessing its impact on daily activities and exercise response is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \>18 years * Chronic cough as per European Respiratory Society definition (\>8 weeks duration) * High symptom burden (i.e., cough visual analogue scale \>40 mm at pre-study screening) * Chest radiograph or CT within 3 years of the screening visit with no abnormalities considered to contribute to chronic cough Exclusion Criteria: * Smokers or individuals who gave up smoking within 12 months * Smoking history \>20 pack-years * Long-COVID or post-COVID syndrome (defined as symptoms lasting over 12-weeks in duration) * Recent exacerbation of cough within 4 weeks of inclusion * Respiratory tract infection within 4 weeks of inclusion * Currently taking any of the following medications: * ACE inhibitors and within 3 months of inclusion * Antitussives (opioids, pregabalin, gabapentin, amitriptyline, nortriptyline, or over the-counter medications) within 2 weeks of inclusion * Medical treatments for gastro-oesophageal reflux disease (GORD), eosinophilic bronchitis or other cough related conditions, initiated or changed (i.e., not in a stable regimen) for 4 weeks prior to inclusion * Medical history of asthma or exercise-induced bronchoconstriction (EIB), COPD, or chronic bronchitis in the judgement of the investigator * Medical conditions/history or other circumstances which, in the judgement of the investigators, could increase the risk of adverse events or bias the study results
Where this trial is running
Leeds, West Yorkshire
- University of Leeds — Leeds, West Yorkshire, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Oliver J Price, PhD
- Email: o.price1@leeds.ac.uk
- Phone: +44(0)113 343 2909
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.