Effects of chicory inulin on gut microbiota in healthy adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how native chicory inulin affects the gut microbiota of healthy adult volunteers. Participants will undergo a one-week run-in phase to establish baseline data before being assigned to receive either chicory inulin or a maltodextrin placebo. The study aims to determine the rate and persistence of changes in gut microbiota, particularly focusing on the growth of Bifidobacterium, in response to the supplementation. Additionally, it will assess the impact of inulin on bowel habits, mood, and appetite.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* adults aged 18-45
* BMI \>18.5 - \< 30 kg/m2
* Regular bowel movements (\> 4 days per week)

Exclusion Criteria:

* Self-reported sensitivity to FODMAPs and following a low FODMAP diet ((FODMAPS stands for fermentable oligosaccharides, disaccharides, monosaccharides and polyols).
* Self-reported food allergies and sensitivities including gluten, dairy, nuts, soya and lactose etc.
* Self-reported antibiotic treatment in the past 6 months.
* Self-reported history of gastrointestinal disease and/or heart disease, cardiovascular, liver, and respiratory disorders, cancer and/or clinically relevant (pre) diabetes.
* Self-reported to having undergone major surgery of the gastrointestinal tract, with the exception of cholecystectomy and appendectomy.
* Self-reported smoking and/or self-reported drug or alcohol abuse.
* Self-reported history of psychiatric and/or mood disorders including eating disorders.
* Self-reported to be following a restrictive diet (i.e. ketogenic, intermittent fasting).
* Pregnant and lactating women.

Where it's running

• Purdue University
  West Lafayette, Indiana, United States Recruiting

Study contacts

• Principal investigator: Stephen Lindemann, PhD — Purdue University
• Study coordinator: Stephen Lindemann, PhD
• Email: lindems@purdue.edu
• Phone: 765-494-9207

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Do Quercefit® or Ubiqsome™ help with aging and metabolic health in adults 50–75?

  This study tests whether Quercefit® or Ubiqsome™ can improve aging markers, blood sugar, and heart health in sedentary adults aged 50–75 compared with a placebo.

  Recruiting Applied Science & Performance Institute · Tampa, Florida · NCT07760506

• NVTIA Ergothioneine for Healthy Aging and Skin Health

  This study tests whether taking NVTIA Ergothioneine daily for 12 weeks helps healthy adults age more gracefully and keeps skin looking and feeling better compared with a placebo.

  Recruiting European Life Science Research Association · Dhaka · NCT07750002

• Miricell supplementation and markers of healthy aging

  This trial tests whether taking Miricell once daily for 12 weeks improves cellular health and brain/metabolic indicators in adults aged 40–70 compared with a placebo.

  Recruiting Nutraland USA, Inc. · Canfield, Ohio · NCT07675200

• Does daily lean beef support brain health in older adults

  In healthy adults aged 65 and up, this study tests whether eating lean beef every day for two weeks can influence brain health markers compared with a non-beef, protein-matched option.

  Recruiting South Dakota State University · Brookings, South Dakota · NCT07623785

• Adaptive computerized training to boost thinking in healthy seniors and those with mild cognitive impairment

  This study tests whether a computer-based training program can improve executive thinking in older adults, including those with mild cognitive impairment, and see if it also helps memory and well-being.

  Recruiting at 2 sites Universidad Antonio de Nebrija · Madrid, Madrid and 1 other locations · NCT07598409

• SHARP: Personalized Health and Behavior Plan to Lower Biological Age in Older Adults

  A 12-month randomized trial tests whether a personalized health and behavior program can lower biological age and improve function in healthy adults over 50.

  Recruiting Sheba Medical Center · Ramat Gan, Tel Aviv · NCT07596576

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.