Effects of cancer treatments on fertility

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate how gonadotoxic treatments, such as chemotherapy and radiotherapy, impact fertility in cancer patients. It focuses on measuring changes in Anti-Müllerian hormone (AMH) levels in females and sperm concentration in males before and after treatment. The study will collect fertility-related data from various centers in Switzerland, Germany, and Austria over a period of up to 15 years. Data will be gathered through routine clinical care and analyzed to understand the long-term effects of these therapies on reproductive health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with cancer or with benign reasons undergoing chemotherapy and/or radiotherapy of the pelvis (females) and the testicles (males) and/or immune therapy;
* Willing to participate;
* Austria: 14-50 years old (adolescents and adults), Germany: 18-50 years old, Switzerland: 14-50 years old (adolescents and adults);
* Serum hormone analysis before gonadotoxic therapy (females) or serum hormone analysis and sperm analysis before gonadotoxic therapy (males).

Exclusion Criteria:

* Missing consent;
* Language barrier.

Where it's running

• University Women's Hospital (Inselspital)
  Bern, Switzerland Recruiting

Study contacts

• Principal investigator: Michael von Wolff, Prof. Dr. — Insel Gruppe AG, University Hospital Bern
• Study coordinator: Michael von Wolff, Prof. Dr.
• Email: michael.vonwolff@insel.ch
• Phone: 0041316321301

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.