Effects of blood flow restriction training on recovery after ACL surgery
Immunometabolic Mechanisms of Blood Flow Restriction Training After Anterior Cruciate Ligament Reconstruction
This study is testing whether blood flow restriction training can help people recover better after ACL surgery by improving how their immune cells work.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Yale University Academic / other |
| Locations | 2 sites (Milford, Connecticut and 1 other locations) |
| Trial ID | NCT05012982 on ClinicalTrials.gov |
What this trial studies
This study evaluates how blood flow restriction (BFR) training impacts immune cell metabolism and gene expression in patients recovering from anterior cruciate ligament (ACL) reconstruction. Participants will undergo two training sessions, one with BFR using an AirBand and one without, while being monitored by a certified therapist. The study aims to determine if BFR can enhance recovery by promoting anabolic responses and energy provision in immune cells. The design is a single-blind crossover, ensuring that the analysis remains unbiased.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 18 to 60 who are recovering from ACL reconstruction and can comply with study procedures.
Not a fit: Patients with serious medical conditions, multiple ligament injuries, or significant comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could improve recovery outcomes and rehabilitation efficiency for patients after ACL surgery.
How similar studies have performed: While the specific application of BFR in ACL recovery is novel, similar studies have shown promising results in other rehabilitation contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Provision of signed and dated informed consent form 2. Stated willingness to comply with all study procedures and availability for two study visits at least 1 week apart 3. All genders, between 18 and 60 years of age 4. In good general health without any underlying medical conditions or prior injury that would place the subject at risk of further injury/illness by participating in the study Exclusion Criteria: 1. Serious medical conditions including cardiovascular, metabolic (diabetes), rheumatologic, pulmonary, or musculoskeletal. 2. Multiple ligament ruptures or trauma 3. Rheumatoid arthritis or other significant comorbidities 4. Lower extremity vascular pathology, including history of deep vein thrombosis 5. Those with a history of sickle cell trait or disease 6. Use of anticoagulant medications 7. Pregnancy 8. Treatment with another investigational drug or other intervention within one month of Study Day 1 9. Current smoker or tobacco use within 3 months of Study Day 1 10. Febrile illness within 2 weeks of Study Day 1
Where this trial is running
Milford, Connecticut and 1 other locations
- Yale New Haven Hospital — Milford, Connecticut, United States (Recruiting)
- Gaylord Outpatient Physical Therapy North Haven Clinic — North Haven, Connecticut, United States (Recruiting)
Study contacts
- Principal investigator: Rachel Perry, PhD — Yale University
- Study coordinator: Rachel Perry, PhD
- Email: rachel.perry@yale.edu
- Phone: 203-506-5179
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.