Effects of beta-glucan on appetite and hormones in overweight adults
Impact of ß-glucan Supplementation During Calorie and Carbohydrate Restriction on Subjective Appetite and Gastrointestinal Appetite Hormones in Overweight Adults.
This study is testing if adding beta-glucan to low-calorie meals can help overweight adults feel less hungry and improve their metabolism.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 25 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | University of Glasgow Academic / other |
| Locations | 1 site (Glasgow) |
| Trial ID | NCT05981404 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates how beta-glucan supplementation during a two-day caloric and carbohydrate restriction affects subjective appetite and gastrointestinal appetite hormones in healthy overweight adults. Participants will undergo two experimental trials, consuming low-calorie meals with and without beta-glucan, while their appetite responses, gastric emptying, and metabolic parameters will be measured. The study aims to understand the relationship between beta-glucan intake, appetite regulation, and insulin sensitivity. Measurements will include blood samples, appetite questionnaires, and metabolic rate assessments conducted at the University of Glasgow.
Who should consider this trial
Good fit: Ideal candidates are healthy overweight women aged 18-50 with a BMI of 27-35 kg/m2 who have maintained stable body weight for at least three months.
Not a fit: Patients who are smokers, on long-term medication, pregnant, lactating, or following restrictive diets may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into effective dietary strategies for managing appetite and improving metabolic health in overweight individuals.
How similar studies have performed: While the specific combination of beta-glucan and caloric restriction is novel, previous studies have shown positive effects of beta-glucan on appetite regulation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Participants will be asked to confirm whether they had stable body weight for at least 3 months and are not following a diet to gain or lose weight. They will also be asked to confirm that they are non-smokers, not on long-term medication, not pregnant or lactating, and have no known food allergies to the ingredients in test meals and to Paracetamol. Exclusion Criteria: Participants will be excluded if they are smokers and have irregular menstruation cycles, use any type of medication, exercised more than 75min a week, were pregnant or lactating. Participants will be required to be free of any medical condition, including having food allergies and stable body weight for at least 3 months preceding the study. Participants will be excluded if they are allergic to paracetamol and any types of food and were following any weight loss diet for the last 3 months, are vegan or vegetarian or follow any diet other than the typical Western diet. Participants will be expected to be not on any kind of dietary supplement at the time of the study.
Where this trial is running
Glasgow
- University of Glasgow — Glasgow, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Dalia Malkova, PhD
- Email: dalia.malkova@glasgow.ac.uk
- Phone: 07753433971
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.