Effects of beetroot juice on sleep regulation
Effects of Nocturnal Inorganic Nitrate Supplementation on Physiological Function
This study tests if drinking beetroot juice can improve sleep quality and brain function in healthy people.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT05864521 on ClinicalTrials.gov |
What this trial studies
This study investigates how acute supplementation with inorganic nitrate from beetroot juice affects sleep regulation and neurovascular physiology in healthy individuals. Participants will receive either an active beetroot juice supplement or a placebo to assess the impact on their sleep quality and related physiological measures. The study aims to provide insights into the potential benefits of dietary nitrates on sleep health.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 18-35 or 65-80 years.
Not a fit: Patients with existing health conditions such as coronary artery disease, diabetes, or sleep disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new dietary interventions for improving sleep quality in healthy adults.
How similar studies have performed: While the effects of dietary nitrates on various health outcomes have been studied, this specific investigation into sleep regulation is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18-35 or 65-80 years of age Exclusion Criteria: * Coronary artery disease * Heart failure * Pregnancy * Diabetes * Sleep disorders * Shift workers * Individuals who typically go to sleep after midnight * Individuals who traveled across ≥2 time zones within one week of study visits * Individuals with a history frequent kidney stones * BMI ≥35.0kg/m2 * Use of nicotine-containing products within the two years preceding study visits * Use of allopurinol, proton pump inhibitors, or other medications/supplements which interfere with the nitrate-nitrite-nitric oxide pathway or outcome measures
Where this trial is running
Rochester, Minnesota
- Mayo Clinic in Rochester — Rochester, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Joshua Bock, PhD — Mayo Clinic
- Study coordinator: Joshua Bock, PhD
- Email: Bock.Joshua@mayo.edu
- Phone: (507) 422-0768
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.