Effects of antiseptics on dental implant infections
Antiseptic Effects on the Dental Implant Internal Surface Microbiome
This study is testing if using disinfectant gels in dental implants can help reduce infections and improve success rates for soldiers who are more likely to face dental issues.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 55 Years |
| Sex | All |
| Sponsor | Madigan Army Medical Center Federal |
| Locations | 1 site (Tacoma, Washington) |
| Trial ID | NCT05024760 on ClinicalTrials.gov |
What this trial studies
This study investigates how the insertion of disinfectant gels, specifically hydrogen peroxide and chlorhexidine, into the internal cavities of dental implants can influence the bacterial load and microbiome composition associated with implant failure. It focuses on soldiers who are at higher risk for dental trauma and subsequent complications due to their unique operational environments. By reducing the bacterial presence, the study aims to improve the success rates of dental implants and decrease the need for surgical revisions. The research is particularly relevant given the high incidence of peri-implantitis and mucositis in implant recipients.
Who should consider this trial
Good fit: Ideal candidates for this study are active duty military personnel aged 18-55 who have at least six months remaining at their local duty station.
Not a fit: Patients who are tobacco users, have metabolic disorders affecting healing, or are currently experiencing active periodontal disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved dental implant success rates and reduced complications for military personnel.
How similar studies have performed: Other studies have indicated that reducing bacterial load can improve outcomes in dental implants, suggesting this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Active duty military * 18-55 years old * Over 6 months remaining at local duty station Exclusion Criteria: * Tobacco user * Medications that affect soft tissue or bone healing * Metabolic disorder that affects soft tissue or bone healing * Active periodontal disease
Where this trial is running
Tacoma, Washington
- Madigan Army Medical Center — Tacoma, Washington, United States (Recruiting)
Study contacts
- Study coordinator: Kevin D Smith, DMD
- Email: kevin.d.smith2.mil@health.mil
- Phone: 253-968-0181
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.