Effects of an unhealthy lifestyle on young active adults
The Effects of an Obesogenic Lifestyle in Recreationally Active, Young Adults
This study tests how changing to a less active lifestyle with more carbs affects insulin and metabolism in young adults who usually exercise.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 45 (estimated) |
| Ages | 18 Years to 30 Years |
| Sex | All |
| Sponsor | University of New Hampshire Academic / other |
| Locations | 1 site (Durham, New Hampshire) |
| Trial ID | NCT05912348 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates how transitioning to an obesogenic lifestyle affects insulin resistance and metabolic flexibility in recreationally active young adults. It aims to determine if adding excess carbohydrates while becoming less active leads to insulin resistance and impaired glucose regulation. The study also explores whether physical activity can mitigate these effects on carbohydrate and fat metabolism. Participants will be divided into groups based on their physical activity levels and carbohydrate intake to assess these changes.
Who should consider this trial
Good fit: Ideal candidates are healthy young adults aged 18-30 who are recreationally active and meet specific fitness criteria.
Not a fit: Patients with pre-existing conditions such as hypertension, diabetes, or cardiovascular disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into preventing obesity and metabolic disorders in young adults transitioning to a sedentary lifestyle.
How similar studies have performed: While previous animal studies have shown similar effects of diet and activity on obesity and insulin resistance, this approach in humans is less explored, making it a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18-30 years of age * Recreationally active completing 75-150 minutes of moderate-to-vigorous intensity exercise (\>2 days/week). * Fair cardiorespiratory fitness levels (Men: VO2\>38.4 ml/kg/min; Women: VO2\>32.6 ml/kg/min). Exclusion Criteria: * Hypertension (resting or diagnosed) * Impaired fasting blood glucose (\>100mg/dL) * Diagnosed cardiovascular disease * Diagnosed diabetes * Diagnosed cancer * Diagnosed chronic kidney disease * Diagnosed musculoskeletal disorders that prevents the individual from exercising on a bike.
Where this trial is running
Durham, New Hampshire
- University of New Hampshire Cardiometabolic Research Laboratory — Durham, New Hampshire, United States (Recruiting)
Study contacts
- Principal investigator: Michael S Brian, PhD — University of New Hampshire
- Study coordinator: Michael Brian, PhD
- Email: Michael.Brian@unh.edu
- Phone: 603-714-8899
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.