Effects of almonds on skin collagen and wrinkles
Prospective Randomized Controlled Trial on the Effects of Almond on Facial Skin Collagen and Wrinkles
This study tests whether eating almonds can improve skin health, reduce wrinkles, and boost collagen in women before and after menopause.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 35 Years to 70 Years |
| Sex | Female |
| Sponsor | Integrative Skin Science and Research Industry-sponsored |
| Drugs / interventions | radiation |
| Locations | 1 site (Sacramento, California) |
| Trial ID | NCT06074276 on ClinicalTrials.gov |
What this trial studies
This study investigates how almond consumption affects collagen production, elastin levels, wrinkles, and pigmentation in premenopausal and postmenopausal women of all Fitzpatrick skin types. Participants will consume whole almonds or a non-nut snack while maintaining their usual diet and skincare products. The study aims to understand the potential benefits of almonds, which are rich in nutrients and antioxidants, on skin health, particularly in relation to aging and hormonal changes.
Who should consider this trial
Good fit: Ideal candidates are women aged 35 to 70, both premenopausal and postmenopausal, with a BMI between 18.5 and 35.
Not a fit: Patients with nut allergies or those currently using collagen or vitamin E supplements may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into dietary interventions that improve skin health and reduce signs of aging.
How similar studies have performed: Previous studies have shown positive effects of almond consumption on skin health, particularly in postmenopausal women, suggesting a promising approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subjects 35 to 70 years of age of all skin types * 50% of the subjects will be postmenopausal women determined as \>1-year loss of menstrual period * 50% of the subjects will be premenopausal women * BMI 18.5 - 35 kg/m2 * Individuals with a habitual diet that has been maintained for at least 6 months and to be maintained for the duration of the study * Individuals must maintain their usual skincare products, defined as products that has been used for at least 1 month, for the duration of the study Exclusion Criteria: * Those with a nut allergy * Those who are unwilling to discontinue oral collagen supplementation 1 month prior to the start of the study * Individuals who are unwilling to discontinue vitamin E or nut containing supplements 2 weeks prior to and during the intervention. * Individuals who are pregnant or breastfeeding * Change in skincare products during the study * Had a medical or cosmetic procedure such as laser resurfacing or plastic surgery to the face within the last 6 months (include botulinum toxin, dermal fillers, collagen, or other similar cosmetic procedure) * Has an autoimmune photosensitive condition or known genetic condition with a deficiency in collagen production (such as Ehler-Danlos) * Those with a skin disease on their face that would affect the assessment of their skin based on the assessment of the investigator. * Current tobacco smoker or a tobacco smoking history of greater than 10 pack-years
Where this trial is running
Sacramento, California
- Integrative Skin Science and Research — Sacramento, California, United States (Recruiting)
Study contacts
- Principal investigator: Raja Sivamani, MD MS AP — Integrative Skin Science and Research
- Study coordinator: Sarah Adnan
- Email: sarah@integrativeskinresearch.com
- Phone: 9168074299
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.