Effects of almond oil and tretinoin on facial wrinkles
Prospective, Double-Blinded, Randomized Study of Topical Almond Oil and Tretinoin on Facial Wrinkles
This study tests if using almond oil, almond oil with vitamin E, or tretinoin can help reduce facial wrinkles and improve skin in post-menopausal women.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Integrative Skin Science and Research Industry-sponsored |
| Locations | 1 site (Sacramento, California) |
| Trial ID | NCT06571721 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of topical almond oil, almond oil with vitamin E, and tretinoin oil on facial wrinkles and skin properties in post-menopausal women. It aims to assess improvements in wrinkle severity, pigmentation, hydration, and skin oil production. The research builds on previous findings that almond consumption can reduce wrinkle severity, exploring how topical applications may yield similar benefits. The study will involve a controlled application of these products to evaluate their effectiveness in enhancing skin appearance.
Who should consider this trial
Good fit: Ideal candidates for this study are post-menopausal women with Fitzpatrick skin types 1, 2, and 3 who have facial fine lines and wrinkles.
Not a fit: Patients who are pregnant, breastfeeding, have nut allergies, or have undergone recent cosmetic procedures may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a natural and effective treatment option for reducing facial wrinkles and improving skin tone in post-menopausal women.
How similar studies have performed: Previous studies have shown positive results with almond consumption for wrinkle improvement, suggesting potential success for this topical application approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Post-menopausal women of Fitzpatrick skin types 1, 2, and 3 * Individuals with facial fine lines and wrinkles Exclusion Criteria: * Individuals who are pregnant or breastfeeding * Prisoners * Adults unable to consent * Those with a nut allergy or tocopherol allergy * Current smokers, those that have smoked within the past year, and former smokers with greater than a 10-pack- year history of smoking * Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndromes) * Those who have undergone any cosmetic procedures to the face in the 3 months prior to enrollment in the opinion of the investigator. People that have undergone deeper chemical peels (TCA based peels) within 1 year prior to enrollment * Individuals who are unwilling to discontinue vitamin E containing supplements and food sources such as all nuts, sunflower seeds or sunflower oil during the washout and intervention * Individual who are unwilling to discontinue topical cosmetic products during the duration of the study or unwilling to undergo a 2-week washout of topicals that are known to modulate collagen and pigment: * Retinoids such as tretinoin, adapalene, retinol, except as provided by the study. * Antioxidant ingredients such as vitamin C or vitamin E. * Pigment reducing agents such as hydroquinone, azelaic acid, kojic acid, or a retinoid except for the retinol that is provided in this study. * Topicals that contain a nut oil or nut extract as part of their ingredient list.
Where this trial is running
Sacramento, California
- Integrative Research Institute — Sacramento, California, United States (Recruiting)
Study contacts
- Study coordinator: Nasima Afzal
- Email: nasima@integrativeskinresearch.com
- Phone: 915-750-2463
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.