Clinical trial Recruiting at 4 sites Observational Ages 10 to 19

Effectiveness of multisystemic therapy for adolescents from families with intellectual disabilities

Official title: The Effectiveness of Multisystemic Therapy for Adolescents With Severe Behavioural Problems From Families With Intellectual Disabilities: A Mixed-Method Study

Run by De Viersprong · NCT06032455 · Data updated 2026-11-12

This study is testing a special therapy for teenagers with serious behavior issues from families with intellectual disabilities to see if it helps them behave better compared to regular therapy.

Quick facts

Study typeObservational
Ages10 Years to 19 Years
SexAll
Enrollment470 (estimated)
SponsorDe Viersprong
Academic / other
Locations4 sites (Halsteren and 3 other locations)
StatusRecruiting
StartedSeptember 4, 2023
Main results expectedSeptember 2027
Study endsSeptember 2027
Registry record updatedApril 13, 2026
Trial IDNCT06032455 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include adolescents aged 10 to 19 with severe behavioral problems and known or suspected intellectual disabilities, living with parents who have custody.

Probably not a fit

Patients who do not have an intellectual disability or do not meet the age and behavioral criteria may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the effectiveness of a specialized form of multisystemic therapy (MST-ID) for adolescents aged 10 to 19 who exhibit severe behavioral problems and come from families with intellectual disabilities. The study employs a mixed-methods approach, combining quantitative assessments of behavioral changes with qualitative feedback from participants and their families. Participants will complete questionnaires at multiple time points to track progress and experiences throughout the treatment process. The goal is to determine if MST-ID is more effective than standard MST in reducing rule-breaking behaviors and to gather insights on the treatment experience.

Why it matters

Potential benefit: If successful, this therapy could significantly improve behavioral outcomes for adolescents with intellectual disabilities and their families.

How similar studies have gone: Pilot studies have shown that MST-ID may provide similar or better outcomes compared to standard MST, indicating potential success for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Referral Criteria:

* Known or suspected ID of the referred adolescent and/or their parent(s);
* Educational level of the referred adolescent and/or highest attained diploma of their parent(s) is indicative of potential ID.

Inclusion Criteria Study Sample:

* Adolescent must be 10 to 19 years old at the start of treatment;
* Adolescent presents with severe behavioural problems in at least two life areas;
* Adolescent lives with a family or there is a family the adolescent can live with, in which parent(s) have parental custody for a longer period of time;
* Parent(s) consent(s) and is/are willing to engage in treatment to prevent an out-of-home placement of the adolescent;
* Adolescent and/or parent(s) have a known or suspected intellectual disability (operationalised as an intelligence quotient \[IQ\] score of between 50-85 and additional deficits in adaptive functioning)
* Adolescent and/or parent(s) have sufficient knowledge of the Dutch language (as assessed by a clinician and/or researcher) in order to understand and answer the various (self-report) questionnaires.

Exclusion Criteria Study Participation:

* Adolescent lives independently;
* Adolescent presents with severe problematic sexual behaviours, without presenting with other severe behavioural problems;
* Adolescent presents suicidal, psychotic, or homicidal requiring specialised treatment (such as a crisis placement in a residential facility);
* Adolescent has a severe Autism Spectrum Disorder (level 2-3 according to the Diagnostic and Statistical Manual of Mental Disorders \[DSM-V\] criteria) or a severe ID (IQ score \<50);
* Adolescent has internalising psychiatric problems which are the primary reason for referral, or has serious psychiatric problems (similar to #3 as well as for example eating disorder.

Where it's running

  • De Viersprong
    Halsteren, Netherlands
    Recruiting
  • Koraal
    Sittard, Netherlands
    Recruiting
  • Stichting Prisma
    Waalwijk, Netherlands
    Recruiting
  • Pactum
    Zetten, Netherlands
    Recruiting

Study contacts

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.