Effect of Vitamin C on Fever During Labor with Epidural Analgesia
Effect of Intravenous Vitamin C on Intrapartum Maternal Fever After Epidural Labor Analgesia : A Randomized Controlled Trial
This study is testing if giving vitamin C to women in labor who receive an epidural can help lower the chance of fever and improve health for both moms and babies.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 400 (estimated) |
| Ages | 18 Years to 35 Years |
| Sex | Female |
| Sponsor | Third Affiliated Hospital of Zhengzhou University Academic / other |
| Locations | 1 site (Zhengzhou, Henan) |
| Trial ID | NCT06354582 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of intravenous vitamin C infusion on maternal fever that occurs during labor after receiving epidural analgesia. Parturients requesting pain relief will be evaluated by obstetricians and anesthesiologists before receiving epidural analgesia. Following the administration of the analgesia, participants will be monitored for adverse reactions and then given either vitamin C or a placebo. The goal is to determine if vitamin C can reduce the incidence of intrapartum fever and improve outcomes for both mothers and infants.
Who should consider this trial
Good fit: Ideal candidates are full-term pregnant women with a single fetus who are planning to have a vaginal delivery and are receiving epidural labor analgesia.
Not a fit: Patients who have pre-existing fever, acute infections, or significant comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved maternal and infant health outcomes during labor.
How similar studies have performed: While the use of vitamin C in various medical contexts has been explored, this specific application in labor analgesia is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * single-fetus, head position, and full-term vaginal delivery receiving epidural labor analgesia. Exclusion Criteria: * have a fever before epidural analgesia, acute infection on admission, incomplete baseline data, fatal fetal malformations or comorbidities, duration from admission to delivery of more than 72 hours or less than 3 hours, or an American Society of Anesthesiologists (ASA) classification of ≥ Ⅲ.
Where this trial is running
Zhengzhou, Henan
- Third Affiliated Hospital of Zhengzhou University — Zhengzhou, Henan, China (Recruiting)
Study contacts
- Study coordinator: Kunyue Li, M.M
- Email: likunyue0312@163.com
- Phone: +8615836298766
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.