Effect of Olanzapine on Weight Gain in Advanced Gynecologic Cancer Patients
Official title: Efficacy of Olanzapine on Weight Gain in Women with Advanced Stage Gynecologic Cancer Receiving Paclitaxel and Carboplatin Combination Chemotherapy : a Double Blind, Placebo-controlled Randomized Trial
Run by Department of Medical Services Ministry of Public Health of Thailand · NCT06288854 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing if the medication olanzapine can help prevent weight gain in patients with advanced gynecologic cancer who are being treated with paclitaxel and carboplatin.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | Women only |
| Enrollment | 48 (estimated) |
| Sponsor | Department of Medical Services Ministry of Public Health of Thailand Government |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Bangkok) |
| Trial ID | NCT06288854 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients with advanced stage gynecologic cancer who are receiving paclitaxel and carboplatin chemotherapy and have a good performance status.
✕Probably not a fit
Patients who are pregnant, have active infections, or have certain medical conditions such as diabetes or morbid obesity may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the efficacy of olanzapine in preventing weight gain among patients with advanced gynecologic cancer who are undergoing treatment with paclitaxel and carboplatin. It is a double-blind, placebo-controlled randomized trial, meaning that neither the participants nor the researchers know who is receiving the olanzapine or the placebo. The study aims to determine the proportion of patients who experience weight gain while on these treatments. Participants must meet specific eligibility criteria, including having normal organ function and being able to communicate in Thai.
Why it matters
Potential benefit: If successful, this study could help manage weight gain in patients undergoing chemotherapy for advanced gynecologic cancer, improving their overall quality of life.
How similar studies have gone: While there is limited data on the specific use of olanzapine for weight gain in this context, similar studies have explored the use of olanzapine for weight management in other patient populations with some success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Advanced stage gynecologic cancer receiving Paclitaxel and carboplatin chemotherapy * ECOG 0-1 * Normal CBC,Liver, renal function * Communication in Thai language or Thai caregiver * Inform consent Exclusion Criteria: * Pregnancy * Active infection * Bowel obstruction or history of bowel surgery * On dopamine receptor antagonists or psychiatric or anticonvulsant medication * Olanzapine allery * Abnormal function of liver and renal * Diabetic melitus or morbid obesity * patient can't selfcare
Where it's running
-
Rajavithi Hospital
Bangkok, Thailand Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.