Effect of NiTi File Systems and XP-Endo Finisher on Postoperative Pain After Root Canal Treatment
Official title: EVALUATION OF THE EFFECT OF RECIPROCATING AND ROTARY NICKEL-TITANIUM FILE SYSTEMS USED IN COMBINATION WITH XP-ENDO FINISHER ON POSTOPERATIVE PAIN FOLLOWING ROOT CANAL TREATMENT
Run by Eskisehir Osmangazi University · NCT07642596 · Data updated 2026-11-12
This study tests whether different NiTi file systems and the XP-Endo Finisher can reduce pain after endodontic treatment in adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Eskisehir Osmangazi University Academic / other |
| Locations | 2 sites (Eskişehir, Odunpazarı and 1 other locations) |
| Status | Recruiting |
| Started | February 13, 2026 |
| Main results expected | February 28, 2027 |
| Study ends | April 30, 2027 |
| Registry record updated | June 11, 2026 |
| Trial ID | NCT07642596 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18-65 requiring root canal treatment for mandibular molars with pulpal necrosis and periapical radiolucent lesions.
✕Probably not a fit
Patients with non-necrotic pulps, acute infections, or anatomy unsuitable for the tested systems may not experience pain reduction.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study compares two rotary NiTi file systems (FKG Race Evo and One Reci) and their combinations with an irrigation-activation device (XP-Endo Finisher) to see which approach best manages postoperative pain after root canal treatment in molar teeth. Participants are adults aged 18-65 with pulpal necrosis and chronic apical periodontitis undergoing endodontic therapy. The study uses randomized or controlled assessment of pain outcomes following treatment with each file system and activation combination, aiming to understand the influence of instrumentation and irrigation enhancements on pain and healing. The protocol emphasizes minimizing apical extrusion and improving disinfection to potentially lower postoperative discomfort. The results may add clinically relevant information to optimize endodontic procedures and patient comfort.
Why it matters
Potential benefit: If successful, patients may experience less postoperative pain and a smoother recovery after root canal treatment.
How similar studies have gone: Previous work suggests that instrumentation and activation devices can influence postoperative pain, but findings vary by system; this study explores this specific combination.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-65 years. Healthy volunteers. Mandibular molar teeth with pulpal necrosis, asymptomatic status, chronic apical periodontitis, and periapical radiolucent lesion. Written informed consent. Exclusion Criteria: * Patients who have taken analgesic or anti-inflammatory drugs within the last 12 hours. Patients with allergy to non-steroidal anti-inflammatory drugs or local anesthetics. Pregnant or lactating patients. Patients with a history of gastrointestinal diseases. Patients using opioid medications. Teeth with calcified canals, resorptive defects, or complex root canal anatomy. Patients with severe periodontal disease. Patients with acute or chronic apical abscess or signs of systemic infection. Immunosuppressed patients.
Where it's running
-
Eskişehir Osmangazi University
Eskişehir, Odunpazarı, Turkey (Türkiye) Recruiting -
Eskişehir Osmangazi University
Eskişehir, Odunpazarı, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Büşra Öztürk — Eskisehir Osmangazi University
- Study coordinator: Büşra Öztürk, Research Assistant
- Email: oztrkbusra95@gmail.com
- Phone: +905546810288
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Different endodontic motor motions during root canals and their effect on pain
This study tests whether using different apical motion modes on endodontic motors during root canal work changes postoperative pain in adults with chronic apical periodontitis.
-
Pain and period life: does menstrual cycle or menopause change pain during root canals?
This study will see if pain during a root canal varies with menstrual cycle phase or menopausal status in adult patients.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.