Effect of High Definition Transcranial Alternating Current Stimulation on Depression
Intervention Effect of High Definition Transcranial Alternating Current Stimulation (HD-tACS) on Depressive Disorder
This study is testing if a new brain stimulation treatment can help reduce suicidal thoughts in people with depression.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Anhui Medical University Academic / other |
| Locations | 1 site (Hefei, Anhui) |
| Trial ID | NCT05932706 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of high definition transcranial alternating current stimulation (HD-tACS) on suicidal ideation in patients diagnosed with depressive disorder. Forty participants will be recruited and randomly assigned to receive either active or sham HD-tACS treatment over a period of seven days. The study will utilize neuropsychological assessments, magnetic resonance imaging (MRI), and electroencephalography (EEG) to evaluate the intervention's impact and underlying neural mechanisms. All participants will undergo structured interviews and routine laboratory examinations before and after the treatment.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 65 with a diagnosis of depressive disorder as per DSM-5 criteria.
Not a fit: Patients with severe somatic diseases, other neurological disorders, or additional mental health conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could provide a novel non-invasive treatment option for patients suffering from depressive disorder.
How similar studies have performed: Other studies have shown promising results with transcranial stimulation techniques, suggesting potential efficacy in treating depressive disorders.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * the patients were diagnosed by more than 2 psychiatrists and met the diagnostic criteria of DSM-5 for depression, and HAMD\>17, BSS\>6, PHQ-15\>5. * the age ranged from 18 to 65 years old, and the length of education was more than 5 years. * the visual acuity or corrected visual acuity is normal, right-handed, can cooperate with the completion of various experimental tests. Exclusion Criteria: * accompanied by severe somatic diseases, such as severe heart, liver, renal insufficiency and so on. * accompanied by other neurological diseases, such as stroke, epilepsy and so on. pregnant and lactating women. * accompanied by other mental disorders, such as drug abuse, schizophrenia, schizophrenic affective
Where this trial is running
Hefei, Anhui
- Yanghua Tian — Hefei, Anhui, China (Recruiting)
Study contacts
- Study coordinator: Kai Wang, PhD
- Email: wangkai1964@126.com
- Phone: +86055162923704
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.