Effect of Genicular Nerve Block on Recovery After Knee Surgery

The Effect of RF Genicular Nerve Block Applied in the Preoperative Period on Fast-track Total Knee Arthroplasty

Observational Pamukkale University · NCT06239649

This study is testing if a special pain-blocking treatment before knee surgery can help patients recover faster and feel better afterward.

Quick facts

Study typeObservational
Enrollment60 (estimated)
Ages40 Years to 85 Years
SexAll
SponsorPamukkale University Academic / other
Locations1 site (Denizli, Pamukkale)
Trial IDNCT06239649 on ClinicalTrials.gov

What this trial studies

This study compares the effectiveness of preoperative radiofrequency genicular nerve ablation in patients undergoing total knee arthroplasty using a Fast-Track protocol. The focus is on assessing postoperative pain management, functional recovery, and early discharge criteria. By reducing pain through this non-surgical intervention, the study aims to enhance patient satisfaction and mobilization after surgery. The approach is based on previous findings that suggest genicular nerve neurolysis can significantly alleviate pain and improve quality of life for patients with knee osteoarthritis.

Who should consider this trial

Good fit: Ideal candidates are individuals aged 40 to 85 who are undergoing unilateral total knee arthroplasty due to primary knee osteoarthritis.

Not a fit: Patients with significant comorbidities, previous psychiatric disorders, or those undergoing revision knee surgery may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to improved pain management and faster recovery for patients undergoing knee surgery.

How similar studies have performed: Previous studies have shown that genicular nerve radiofrequency ablation is effective in reducing pain and improving function in similar patient populations.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Being between the ages of 40 and 85,
* Being able to understand verbal and written information given in Turkish,
* Being able to speak and understand Turkish,
* Being subjected to unilateral TKA surgery due to the diagnosis of Primary Knee osteoarthritis

Exclusion Criteria:

* Patients planned for revision knee prosthesis surgery,
* Patients previously diagnosed with psychiatric disorders,
* Patients who have undergone major surgery on the extremity where TKA will be applied,
* Patients with comorbid diseases such as rheumatoid arthritis or cancer,
* Patients with a score above 3 according to the American Society of Anesthesiologists (ASA) scoring,
* Patients with neurological diseases that cause functional disability,
* Patients with flexion limitation of more than 45 degrees and extension limitation of more than 20 degrees,
* Patients who have to use hypnotic or anxiolytic drugs regularly,
* Patients with alcohol or drug addiction,
* Patients with bleeding disorders
* Patients with uncontrolled diabetes

Where this trial is running

Denizli, Pamukkale

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Knee OsteoarthritisKnee Pain ChronicFast-Track Total Knee ArthroplastyGenicular Nerve BlockRadiofrequency Ablation
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.