Effect of exercise on knee osteoarthritis
Effect of Nordic Walking and Inspiratory Muscle Training to Promote Cardiopulmonary Function in Patients With Knee Osteoarthritis
This study is testing if Nordic walking and breathing exercises can help people with knee osteoarthritis feel less pain and breathe better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 55 Years and up |
| Sex | All |
| Sponsor | The Hong Kong Polytechnic University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Kowloon City, Kowloon) |
| Trial ID | NCT06084949 on ClinicalTrials.gov |
What this trial studies
This randomized controlled trial evaluates the impact of Nordic walking and inspiratory muscle training on cardiopulmonary function in patients with knee osteoarthritis. Participants are divided into groups based on the severity of their condition, with mild-to-moderate cases receiving Nordic walking alongside routine management, while end-stage cases undergo inspiratory muscle training with pre-operative rehabilitation. The study aims to assess improvements in cardiopulmonary function, pain reduction, and overall disability through structured exercise interventions. Two assessments will be conducted to compare outcomes between intervention and control groups.
Who should consider this trial
Good fit: Ideal candidates include individuals with mild-to-moderate knee osteoarthritis experiencing pain and difficulty in daily activities.
Not a fit: Patients who have undergone knee surgery or have inflammatory arthritis may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance physical function and reduce pain for patients with knee osteoarthritis through structured exercise.
How similar studies have performed: Other studies have shown positive outcomes with exercise interventions for knee osteoarthritis, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * pain on the most days in one or both knees in the past month; * difficulty with at least one of daily living activities measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scale; * radiographic evidence of knee OA in the tibial-femoral compartment (Kellgren and Lawrence grade, K/L ≥1, K/L 1-3 regarded as mild-to-moderate knee OA, others waiting for knee arthroplasty regarded as end-stage knee OA); * with normal or corrected visual and auditory function and walking unaided; * primary knee OA for more than 6 months, be stable on medication for at least 3 weeks. Exclusion Criteria: * knee surgery priorly; * have steroid injection in previous three weeks; * have inflammatory arthritis (e.g., rheumatoid); or unstable angina, or myocardial infarction, or cardiac surgery; or stroke; or treatment with steroids, hormones, or cancer chemotherapy; or pulmonary diseases (force vital capacity\<80% of predicted and/or forced expiratory volume at first second\<70% of predicted); or a history of exercise-induced asthma; * unable to understand the procedure and potential risks of the study; * medically unstable that indicate unsafe to participate in exercise test
Where this trial is running
Kowloon City, Kowloon
- The Hong Kong Polytechnic University — Kowloon City, Kowloon, Hong Kong (Recruiting)
Study contacts
- Principal investigator: Amy FU, PhD — Department of Rehabilitation Sciences
- Study coordinator: Tracy Tang
- Email: tracy-wh.tang@polyu.edu.hk
- Phone: +852 3400 8541
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.