Effect of exercise on fatigue and depression in multiple sclerosis patients
Cardiovascular Fitness and the Influence of a Controlled Combined Exercise Program on Fatigue and Depression of Newly Diagnosed Patients With Multiple Sclerosis
This study tests if a structured exercise program can help newly diagnosed multiple sclerosis patients feel less tired and depressed compared to regular rehabilitation.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 70 (estimated) |
| Ages | 20 Years to 45 Years |
| Sex | All |
| Sponsor | University Hospital Ostrava Academic / other |
| Locations | 1 site (Ostrava, Moravian-Silesian Region) |
| Trial ID | NCT05671588 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of controlled combined exercise on cardiovascular fitness, fatigue, and depression in newly diagnosed patients with multiple sclerosis (MS). It aims to determine whether early rehabilitation interventions can improve quality of life and motivate patients to adopt a more active lifestyle. Participants will be divided into two groups: one receiving a structured exercise program and the other undergoing conventional rehabilitation. The study will assess the effectiveness of these interventions over a period of two months, focusing on the changes in fatigue and depression levels.
Who should consider this trial
Good fit: Ideal candidates are adults aged 20 to 45 who have been newly diagnosed with relapsing-remitting multiple sclerosis or clinically isolated syndrome.
Not a fit: Patients with progressive forms of multiple sclerosis or those who cannot participate in the exercise program due to medical contraindications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management of fatigue and depression in patients with multiple sclerosis, enhancing their overall quality of life.
How similar studies have performed: Previous studies have shown that aerobic exercise can improve fatigue in MS patients, suggesting that this approach may be beneficial, although the specific combined exercise protocol is less commonly tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 20 - 45 years * Newly diagnosed patients with multiple sclerosis * Relapsing-remitting MS (RRMS) or clinically isolated syndrome (CIS) * EDSS 0-6 * Signed informed consent Exclusion Criteria: * Progressive forms of MS (PRMS or SPMS), Malignant MS * Non-cooperation, disagreement with the study * Contraindication to spiroergometry
Where this trial is running
Ostrava, Moravian-Silesian Region
- University Hospital Ostrava — Ostrava, Moravian-Silesian Region, Czechia (Recruiting)
Study contacts
- Principal investigator: Anna Šilarová, MD — University Hospital Ostrava
- Study coordinator: Jiří Hynčica
- Email: jiri.hyncica@fno.cz
- Phone: 0042059737
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.