Effect of dental cleaning on saliva and gum fluid in patients with gum disease compared to healthy individuals
Effect Of Scaling and Root Planning on Alkaline Phosphatase in Saliva and Gingival Crevicular Fluid in Periodontitis Patients Compared With Healthy Subjects Before and After Treatment
This study tests if dental cleaning can lower certain enzyme levels in saliva and gum fluid for people with gum disease compared to those with healthy gums.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 134 (estimated) |
| Ages | 15 Years to 60 Years |
| Sex | All |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Giza, Haram) |
| Trial ID | NCT06048016 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the impact of scaling and root planning on alkaline phosphatase levels in saliva and gingival crevicular fluid among patients with periodontitis compared to healthy individuals. The study will involve participants maintaining their oral hygiene while researchers assess the differences in alkaline phosphatase levels. By comparing these two groups, the trial seeks to provide insights into the effectiveness of dental cleaning procedures in managing periodontal disease.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with stage I-IV periodontitis who have more than 10 remaining teeth and are systemically healthy.
Not a fit: Patients with infectious diseases requiring antibiotics, inflammatory diseases needing analgesics, diabetes, hypertension, thyroid disease, recent periodontal treatment, pregnancy, lactation, or those who smoke may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of periodontal disease management and improve treatment strategies for patients with gum disease.
How similar studies have performed: While this approach is based on established periodontal treatment methods, the specific focus on alkaline phosphatase as a biomarker in this context may provide novel insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * periodontitis patients stage I,II,III,IV Having more than 10 remaining teeth. • Systemically free Exclusion Criteria: * infectious diseases dependent on antibiotics. .inflammatory diseases depend on analgesics. . Diabetes mellites patients . Hypertensive patients .Thyroid disease * Patients who had professional periodontal treatment during the last 6 months. * Pregnancy or lactation. * Smokers.
Where this trial is running
Giza, Haram
- Zahraa Nasser — Giza, Haram, Egypt (Recruiting)
Study contacts
- Principal investigator: Zahraa Af Nasser — Cairo University
- Study coordinator: Zahraa AF Nasser, Master's
- Email: zahraa.a.nasser@gmail.com
- Phone: 01127670057
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.