Effect of Central Sensitization on Shoulder Steroid Injection Response
Investigation of the Effect of Central Sensitization on Steroid Injection Response in Patients With Shoulder Pain Secondary to Rotator Cuff Lesion
NA · Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey · NCT05926895
This study is testing if having central sensitization affects how well steroid injections work for people with shoulder problems like rotator cuff injuries and impingement syndrome.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 36 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey (other) |
| Locations | 1 site (Istanbul) |
| Trial ID | NCT05926895 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates how the presence of central sensitization affects the response to steroid injections in patients with rotator cuff lesions and subacromial impingement syndrome. Participants will receive an injection of a steroid and anesthetic mixture into the subacromial space, and their treatment responses will be monitored. The study aims to determine if central sensitization is linked to decreased effectiveness of the injection and whether patients with central sensitization exhibit different clinical features compared to those without. This research addresses a significant gap in understanding the impact of pain sensitization on treatment outcomes for shoulder pain.
Who should consider this trial
Good fit: Ideal candidates are individuals with clinically and radiologically confirmed rotator cuff pathology who have not responded to prior medical or physical treatments.
Not a fit: Patients with a history of shoulder trauma, previous shoulder surgery, or those currently using centrally acting medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for patients with shoulder pain by identifying factors that influence the effectiveness of steroid injections.
How similar studies have performed: While there is increasing evidence that central sensitization affects treatment responses, this specific investigation into its impact on shoulder steroid injections is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Rotator cuff pathology confirmed clinically and radiologically (USG/MRI) * Failure to respond to medical/physical treatment * Agree to participate in the study Exclusion Criteria: * Shoulder trauma and history of previous shoulder surgery * History of injection to the painful shoulder in the last 3 months * Use of centrally acting drugs (antidepressants, pregabalin, gabapentin and myorelaxant etc.) * History of active cancer, systemic inflammatory disease, and infection * Pregnancy
Where this trial is running
Istanbul
- Sultan Abdülhamid Han Research and Training Hospital — Istanbul, Turkey (RECRUITING)
Study contacts
- Study coordinator: Feyza Nur Yücel, Specialist
- Email: dr.fny28@gmail.com
- Phone: +905385577059
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Central Sensitisation, Subacromial Impingement Syndrome, central sensitisation, central sensitization inventory, subacromial impingement, shoulder pain, steroid injection