Effect of Boswellia on bacteria and inflammation in root canals
Effectiveness of Boswellia as Intracanal Medication on Infectious/Inflammatory Contents in Teeth With Apical Periodontitis
PHASE2; PHASE3 · Mansoura University · NCT06466538
This study is testing if a new treatment with Boswellia can reduce bacteria and inflammation in the root canals of teeth with infection, compared to standard treatments.
Quick facts
| Phase | PHASE2; PHASE3 |
|---|---|
| Study type | Interventional |
| Enrollment | 36 (estimated) |
| Ages | 20 Years to 60 Years |
| Sex | All |
| Sponsor | Mansoura University (other) |
| Locations | 1 site (Al Mansurah) |
| Trial ID | NCT06466538 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of Boswellia-based intracanal medication compared to traditional treatments like calcium hydroxide and Ledermix in reducing bacteria and inflammatory cytokines in root canals of teeth affected by apical periodontitis. The research focuses on the inflammatory response caused by bacterial infections in the periradicular tissues and aims to identify an optimal disinfection protocol. Participants will be treated with one of the three medications, and the levels of bacteria and inflammatory markers will be measured to assess the outcomes.
Who should consider this trial
Good fit: Ideal candidates are adults aged 20 to 60 with single-rooted teeth suffering from pulp necrosis and apical periodontitis.
Not a fit: Patients currently on antibiotic treatment, those with systemic diseases, or teeth that cannot be isolated with a rubber dam will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective treatments for apical periodontitis, improving patient outcomes and reducing inflammation.
How similar studies have performed: While the use of Boswellia in dental treatments is less common, similar studies exploring alternative intracanal medications have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Single-rooted with pulp necrosis and apical periodontitis. * The age range from 20 to 60 years Exclusion Criteria: * Receiving antibiotic treatment within the preceding 3 months. * Reporting systemic disease. * Teeth that could not be isolated with rubber dam. * Teeth with periodontal pockets deeper than 3 mm.
Where this trial is running
Al Mansurah
- May Abuzoor — Al Mansurah, Egypt (RECRUITING)
Study contacts
- Study coordinator: May Abuzoor, phD
- Email: drmayzoor@hotmail.com
- Phone: 0096599182767
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Microbial Colonization