Echocardiogram signs that predict outcomes for people hospitalized with worsening heart failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, single-center observational project at Istanbul University-Cerrahpaşa Cardiology Institute enrolling adults admitted with acute decompensated heart failure. Detailed transthoracic echocardiography will be performed at admission before the first intravenous diuretic dose to capture left- and right-heart structural and functional parameters, including measures related to RV–PA coupling. Clinical data, comorbidities, and vital signs will be recorded and linked to short- and longer-term clinical outcomes. An a priori power calculation determined a target enrollment of at least 76 patients, with enrollment planned between December 2024 and December 2025.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged ≥18 years.
* Hospitalization due to acute decompensated heart failure.
* Intravenous diuretic therapy deemed necessary by the treating cardiologist.
* Predominant left-sided heart failure.
* Provision of written informed consent prior to participation.

Exclusion Criteria:

* Severe anemia (hemoglobin \<7 g/dL).
* Requirement for renal replacement therapy, including hemodialysis or peritoneal dialysis, or being listed for kidney transplantation.
* Severe primary mitral regurgitation.
* Severe aortic stenosis.
* Severe aortic regurgitation.
* Severe primary tricuspid regurgitation.
* Primary right heart failure.
* Heart failure secondary to congenital heart disease.
* History of mitral valve replacement.
* History of aortic valve replacement.
* History of bioprosthetic valve replacement.
* History of transcatheter aortic valve implantation.
* Presence of active malignancy.
* Failure to provide written informed consent.
* Inability to perform transthoracic echocardiography prior to intravenous diuretic therapy for any reason.

Where it's running

• Istanbul University Cerrahpaşa Institute of Cardiology
  Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Aybike G Taşdelen Acar, MD
• Email: aybikegul.tasdelen@iuc.edu.tr
• Phone: +905356955610

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.