Early Trauma and Odor-Triggered Dopamine Release

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, double-blind, parallel-group study will compare dopamine release evoked by positive-odor exposure between two groups defined by childhood trauma history. Thirty adults will undergo MRI-PET scans while smelling pleasant odors, with dopamine activity assessed via [11C]Raclopride binding. Participants are grouped by high versus low Childhood Trauma Questionnaire scores and non-smokers who can read and speak French, with exclusions for olfactory disorders and several medical or psychiatric conditions. The study aims to illuminate how early trauma might shape hedonic olfactory processing and dopaminergic transmission in emotion and reward circuits.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18 years or older
* Have been selected based on the Childhood Trauma Questionnaire score
* Non-smoker
* Be able to speak and read French
* Sign a consent form before intervention.

Exclusion Criteria:

* A pre-existing condition that affects olfaction including congenital anosmia, upper respiratory tract infection, nasal and/or sinus disease,
* Be on medication, with the exception of oral contraceptives
* Pregnant or breast-feeding woman (check with urine pregnancy tests);
* Contraindications to TMS or MRI (implanted medical devices or metallic foreign body in the head);
* Psychiatric disorders
* Use of psychotropic drugs
* Have participated in a study involving the injection of a radiotracer during the year

Where it's running

• CH le Vinatier
  Bron, France Recruiting

Study contacts

• Study coordinator: Filipe Galvao
• Email: filipe.galvao@ch-le-vinatier.fr
• Phone: 0033437915565

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.