Early renal replacement therapy for acute kidney injury after heart surgery
Early Application of Renal-Replacement Therapy in Patients With Acute Kidney Injury After Cardiac Surgery: A Multicenter Randomized Controlled Trial
This study is testing if starting kidney treatment right away after heart surgery can help patients with kidney problems recover better and reduce the risk of dying compared to waiting for treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 202 (estimated) |
| Ages | 19 Years and up |
| Sex | All |
| Sponsor | Seoul National University Hospital Academic / other |
| Locations | 2 sites (Seongnam and 1 other locations) |
| Trial ID | NCT05175053 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of early initiation of renal replacement therapy (RRT) in patients who develop acute kidney injury (AKI) after cardiac surgery. It is a multi-center randomized controlled trial involving 202 patients, who will be divided into two groups: one receiving early RRT within 6 hours of AKI diagnosis and the other receiving delayed RRT based on specific clinical indications. The primary goal is to determine whether early RRT can reduce surgical mortality compared to the standard delayed approach. The study aims to provide clearer guidelines on the timing of RRT initiation in post-operative AKI patients.
Who should consider this trial
Good fit: Ideal candidates include patients who have undergone cardiac surgery and developed AKI classified as KDIGO stage 2 within 7 days post-surgery.
Not a fit: Patients who have previously undergone renal replacement therapy or have AKI due to obstructive nephropathy or prior kidney transplantation may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce mortality rates in patients experiencing acute kidney injury after cardiac surgery.
How similar studies have performed: Previous studies have indicated potential benefits of early RRT in similar patient populations, but this specific approach is being tested for the first time in this context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients within 7 days after cardiac surgery * Acute kidney injury (AKI) described as Kidney Disease: Improving Global Outcomes (KDIGO) stage 2 (urine output \<0.5mL/kg/h for ≥6h or 2-fold increase in serum creatinine compared with baseline) Exclusion Criteria: * previous renal replacement therapy * AKI secondary to obstructive nephropathy * previous kidney transplantation
Where this trial is running
Seongnam and 1 other locations
- Seoul National University Bundang Hospital — Seongnam, Korea, Republic of (Recruiting)
- Seoul National University Hospital — Seoul, Korea, Republic of (Recruiting)
Study contacts
- Principal investigator: Ho Young Hwang, MD, PhD — Seoul National University Hospital
- Study coordinator: Ho Young Hwang, MD, PhD
- Email: scalpel@hanmail.net
- Phone: 82-2-2072-3020
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.