Early recognition of sepsis in children using the Phoenix score

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project analyzes whether the Phoenix Sepsis Score can help identify children under 18 with suspected infection who are at higher risk of in-hospital mortality. It develops and validates the Sepsis Optimal Recognition Toolkit (SORT) for use in diverse hospital settings. The study also assesses how feasible and acceptable it is to implement Phoenix criteria in routine practice across participating centers in Asia. Data will come from multiple international sites with differing resource levels to explore performance and adoption barriers. Interventions focus on applying the Phoenix Sepsis Score to determine risk and guide potential clinical actions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Children \< 18 years old
* Suspected infection defined by (1) blood culture performed (irrespective of result), AND (2) use of broad-spectrum anti-microbial agents, in the first 24 hours of admission

Exclusion Criteria:

* 18 years and older
* Patients who discharge At Own Risk (AOR) without outcome data

Where it's running

• Hospital Tengku Ampuan Rahimah
  Klang, Malaysia Recruiting
• KK Women's and Children' Hospital
  Singapore, Singapore Recruiting
• National University Hospital
  Singapore, Singapore Recruiting
• National Taiwan University Hospital
  Taipei, Taiwan Recruiting
• King Chulalongkorn Memorial Hospital
  Bangkok, Thailand Recruiting
• Shanghai Children's Medical Center, Shanghai Jiaotong University
  Shanghai, China Not yet recruiting

Study contacts

• Study coordinator: Chong Shu-Ling Dr, MBBS, MRCPCH, MCI, MPH
• Email: Chong.Shu-Ling@kkh.com.sg
• Phone: 65 -81211519

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Ruta C and Vitamin C in Sepsis: Adding antioxidants to standard care

  This trial tests whether adding Ruta C (rutin plus vitamin C) or vitamin C alone to standard sepsis treatment helps adults in the ICU stay shorter and recover better.

  Recruiting Ain Shams University · Cairo, Cairo Governorate · NCT07922213

• Early detection of sepsis-related blood clotting problems in severe burn patients

  This study tests how well the JAAM-2 score can detect sepsis-induced coagulopathy early in adults with severe burns who develop sepsis in the ICU.

  Recruiting Center for Traumatology and Major Burns, Ben Arous · Tunis · NCT07914205

• Neutrophil EMR3 as a biomarker for sepsis in ICU patients

  Researchers will test whether measuring EMR3 on neutrophils helps diagnose sepsis, monitor progression, and predict outcomes in adults in Chinese ICUs.

  Recruiting Sir Run Run Shaw Hospital · Hangzhou, Zhejiang · NCT07896018

• Thymalfasin added to standard care for adults with sepsis and immune dysfunction

  This study tests whether thymosin alpha-1 helps restore immune function in adults with sepsis who have weakened immunity.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07866118

• Multicenter group study of sepsis and ARDS in China

  This study tests how sepsis and ARDS differ among adults across several Chinese hospitals and builds a biobank to understand why some patients do better or worse.

  Recruiting at 24 sites Shanghai Zhongshan Hospital · Xiamen, Fujian and 23 other locations · NCT07863908

• Non-invasive hemodynamic guidance for sepsis care on medical wards

  This trial tests whether guiding fluid and vasopressor therapy for sepsis using non-invasive hemodynamic measurements works better than standard care.

  Recruiting at 2 sites Regione del Veneto - AULSS n. 7 Pedemontana · Pisa, Pisa and 1 other locations · NCT07863323

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.