Early-Onset GI Cancer: From Tumor Features to Patient Habits
Official title: A Prospective Observational Study on of Early-Onset Gastrointestinal Cancer: From Tumor Features to Patient Lifestyle Habits - YOGICO Study
Run by Gruppo Oncologico Italiano di Ricerca Clinica · NCT07479472 · Data updated 2026-11-12
This study tests how tumor biology and a patient’s lifestyle choices come together in people diagnosed with early-onset gastrointestinal cancer.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 49 Years |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Gruppo Oncologico Italiano di Ricerca Clinica Academic / other |
| Locations | 11 sites (Bologna, BO and 10 other locations) |
| Status | Recruiting |
| Started | July 30, 2026 |
| Main results expected | April 2028 |
| Study ends | April 2028 |
| Registry record updated | October 6, 2026 |
| Trial ID | NCT07479472 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–49 years with newly diagnosed colorectal, gastroesophageal, or pancreatic cancer, at any stage or treatment plan, who can consent and comply with study procedures.
✕Probably not a fit
Patients who are not interested in lifestyle data collection or who have complex barriers to long-term participation may derive no direct benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational study across multiple centers in northern Italy that will enroll 150–200 adults aged 18–49 with newly diagnosed early-onset GI cancers. Researchers will collect clinical, tumorbiological, and lifestyle data to describe patterns and potential links between tumor features and everyday habits. Participation does not change cancer treatment and follows standard clinical practice at each center. The study emphasizes a holistic view of disease characteristics without assigning specific interventions. Results may improve understanding of how lifestyle factors relate to disease presentation and progression in this population.
Why it matters
Potential benefit: If successful, the study could improve understanding of how lifestyle factors relate to early-onset GI cancer and guide future research or patient counseling.
How similar studies have gone: Previous observational work in oncology has yielded insights from holistic data collection, but this exact approach in early-onset GI cancer is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Provide a signed and dated informed consent form (ICF) * Willing to comply with all study procedures and be available for the duration of the study * Male or female, aged 18-49 years old at time of EoGI cancer diagnosis * Patients with newly diagnosed early-onset gastrointestinal cancer histologically confirmed: colorectal, gastroesophageal and pancreatic tumor site, regardless of histological type * Any disease stage, performance status, and type of treatment, including experimental therapies and supportive care * Previous or concomitant malignancies are allowed provided they do not involve the gastrointestinal tract Exclusion Criteria: * Cognitive, linguistic, or physical barriers that prevent a detailed reconstruction of the patient's personal medical history including past lifestyle habits * Having previously received any treatments directed at the newly diagnosed EOGI cancer (i.e., at the time of inclusion, the patient has not yet started any type of treatment, excluding surgery)
Where it's running
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Oncologia di Prossimità, Ospedale di Carpi e DHO Mirandola, Ausl Modena
Carpi, Mo, Italy Recruiting -
Oncologia Area Sud Ausl Modena
Sassuolo, Mo, Italy Recruiting -
Oncologia, Azienda Ospedaliero Universitaria di Parma
Parma, Pr, Italy Recruiting -
Oncologia Medica, CORE Azienda USL-IRCCS Reggio Emilia
Reggio Emilia, Re, Italy Recruiting -
Oncologia, Ospedale di Rimini
Rimini, Rn, Italy Recruiting -
Oncologia, Ospedale Sant'Orsola
Bologna, Bo, Italy Not yet recruiting
Show 5 more locations
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Istituto Romagnolo per lo studio dei tumori "Dino Amadori", IRCCS IRST
Meldola, Fc, Italy Active not recruiting -
Oncologia Ospedale Carlo Poma di Mantova
Mantua, Minnesota, Italy Active not recruiting -
Centro Oncologico Modenese, Azienda Policlinico Universitaria di Modena
Modena, Mo, Italy Active not recruiting -
Oncologia Medica, AUSL Piacenza
Piacenza, PC, Italy Active not recruiting -
Oncologia, ASST SETTE LAGHI, Ospedale di Circolo
Varese, VA, Italy Not yet recruiting
Study contacts
- Study coordinator: Ilaria Bernardini, MD
- Email: i.bernardini@ausl.mo.it
- Phone: +39 059659294
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.