Early heart muscle changes to spot severe pediatric lupus
Official title: Myocardial Dysfunction in Pediatric Lupus
Run by Shanghai Jiao Tong University School of Medicine · NCT07425730 · Data updated 2026-11-12
This project will test whether non-invasive heart ultrasound measurements can help identify children with severe, treatment-resistant lupus.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 7 Years to 17 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Shanghai Jiao Tong University School of Medicine Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Status | Recruiting |
| Started | February 1, 2026 |
| Main results expected | July 2026 |
| Study ends | July 1, 2026 |
| Registry record updated | April 28, 2026 |
| Trial ID | NCT07425730 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children with SLE onset before age 18 who meet ACR criteria and do not have concurrent malignancy or active infection are the ideal candidates.
✕Probably not a fit
Patients with a history of cancer, active infections, adult-onset SLE, or whose heart imaging does not show dysfunction are unlikely to benefit directly from the findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study uses advanced echocardiography, including global longitudinal strain (GLS), together with clinical data and biomarkers to detect early myocardial dysfunction in pediatric SLE. Eligible participants are children whose disease began before age 18 and who meet American College of Rheumatology criteria, with exclusions for malignancy or active infections. Investigators will compare echocardiographic measures to clinical severity to see if early heart changes mark severe refractory disease. The work is conducted at Shanghai Children's Medical Center and does not involve experimental treatments.
Why it matters
Potential benefit: If successful, this could allow earlier identification of children with severe refractory SLE so clinicians can intensify monitoring and tailor treatments sooner.
How similar studies have gone: Prior studies using GLS have shown left ventricular dysfunction is common in SLE and correlates with disease severity, but no validated biomarkers for early identification of pediatric SR-SLE currently exist.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * fulfill the American College of Rheumatology (ACR) criteria * disease onset at ages before 18 years Exclusion Criteria: * patients with a history of concomitant malignancy * patients with active bacterial, viral, fungal, mycobacterial infection
Where it's running
-
Shanghai Children's Medical Center
Shanghai, Shanghai Municipality, China Recruiting
Study contacts
- Principal investigator: Bao — Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.