Dynamic Infection Kinetics for Early Sepsis Diagnosis and Monitoring in Adult Oncology Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational cohort study conducted at Sohag Oncology Center. It will enroll adult patients with solid or hematologic cancers who have suspected sepsis and at least one blood culture collected as part of routine care. Researchers will collect clinical, laboratory, and microbiological data, including blood culture results, time to positivity, culture clearance, CRP, and procalcitonin levels, to examine dynamic infection kinetics. The goal is to see if serial biomarker and culture metrics improve early detection of sepsis and provide insight into disease severity and treatment response. Interventions are not part of the study; data are observed from standard clinical practice.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Confirmed diagnosis of a solid or hematological malignancy.
* Clinical suspicion of sepsis according to treating physicians.
* At least one blood culture obtained before or shortly after initiation of antimicrobial therapy.
* Availability for clinical follow-up during hospitalization.

Exclusion Criteria:

* Patients receive palliative care only.
* Absence of blood culture sampling.
* Incomplete clinical or laboratory data.
* Refusal to participate in the study, when applicable.

Where it's running

• Sohag Oncology Center
  Sohag, Sohag Governorate, Egypt Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Ruta C and Vitamin C in Sepsis: Adding antioxidants to standard care

  This trial tests whether adding Ruta C (rutin plus vitamin C) or vitamin C alone to standard sepsis treatment helps adults in the ICU stay shorter and recover better.

  Recruiting Ain Shams University · Cairo, Cairo Governorate · NCT07922213

• Early detection of sepsis-related blood clotting problems in severe burn patients

  This study tests how well the JAAM-2 score can detect sepsis-induced coagulopathy early in adults with severe burns who develop sepsis in the ICU.

  Recruiting Center for Traumatology and Major Burns, Ben Arous · Tunis · NCT07914205

• Neutrophil EMR3 as a biomarker for sepsis in ICU patients

  Researchers will test whether measuring EMR3 on neutrophils helps diagnose sepsis, monitor progression, and predict outcomes in adults in Chinese ICUs.

  Recruiting Sir Run Run Shaw Hospital · Hangzhou, Zhejiang · NCT07896018

• Thymalfasin added to standard care for adults with sepsis and immune dysfunction

  This study tests whether thymosin alpha-1 helps restore immune function in adults with sepsis who have weakened immunity.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07866118

• Multicenter group study of sepsis and ARDS in China

  This study tests how sepsis and ARDS differ among adults across several Chinese hospitals and builds a biobank to understand why some patients do better or worse.

  Recruiting at 24 sites Shanghai Zhongshan Hospital · Xiamen, Fujian and 23 other locations · NCT07863908

• Non-invasive hemodynamic guidance for sepsis care on medical wards

  This trial tests whether guiding fluid and vasopressor therapy for sepsis using non-invasive hemodynamic measurements works better than standard care.

  Recruiting at 2 sites Regione del Veneto - AULSS n. 7 Pedemontana · Pisa, Pisa and 1 other locations · NCT07863323

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.