Duodenal organoids to study how the gut lining interacts with pathogens
Official title: Development of an in Vitro Model Based on Human Duodenal Organoids for the Study of Host-Intestinal Pathogen Interactions
Run by IRCCS Sacro Cuore Don Calabria di Negrar · NCT07828665 · Data updated 2026-11-12
Researchers are using tissue from patients who have part of their duodenum removed to grow living 3D organoids and test how the intestinal epithelium responds to pathogens in the lab.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 6 (estimated) |
| Sponsor | IRCCS Sacro Cuore Don Calabria di Negrar Academic / other |
| Locations | 1 site (Negrar, Verona) |
| Status | Recruiting |
| Started | June 9, 2026 |
| Main results expected | December 2027 |
| Study ends | December 2027 |
| Registry record updated | September 18, 2026 |
| Trial ID | NCT07828665 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults undergoing duodenal surgery with histologically normal tissue available for research and who can provide informed consent.
✕Probably not a fit
Patients whose tissue cannot be donated or who do not meet consent requirements may not benefit from this research.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project develops an in vitro model using human duodenal organoids created from patient tissue. Donated samples are used to grow and differentiate organoids, then cultured at air-liquid interfaces to study interactions with enteric pathogens and their components. The work includes assessing pathogen viability and host epithelial responses, along with transcriptomic and proteomic analyses. The study is observational in nature and relies on donated biological material rather than testing in patients.
Why it matters
Potential benefit: If successful, the model could provide a better platform for understanding gut pathogen interactions and for testing therapies in a controlled lab setting.
How similar studies have gone: Other organoid-based models have shown promise for studying host–pathogen interactions, supporting feasibility of this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients subjected to surgical removal of a portion of the duodenum for clinical indications, with availability of histologically normal duodenal tissue; * Availability of written informed consent for the use of biological samples for research purposes. Exclusion Criteria: * Absence of informed written consent * Inadequate amount of histologically normal duodenal tissue
Where it's running
-
IRCCS Ospedale Sacro Cuore Don Calabria
Negrar, Verona, Italy Recruiting
Study contacts
- Study coordinator: Elvia Malo, Dr.
- Email: ricerca.clinica@sacrocuore.it
- Phone: +39 0456014854
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Organoid Drug Sensitivity-Guided Therapy for Refractory Tumors
This study tests whether tumor organoids created from a patient’s tissue can help doctors pick drugs for adults with hard‑to-treat, unresectable, or metastatic cancers after standard options have been exhausted.
-
Testing drug responses using glioblastoma organoids
This study is testing if lab-grown brain tumor samples from patients can help predict how well different drugs will work for their glioblastoma treatment.
-
Collecting tumor samples from triple-negative breast cancer patients to explore new treatments and biomarkers.
This study is collecting tumor samples from people with triple-negative breast cancer to see if new treatments and markers can help improve their care.
-
Using patient-derived organoids to predict lung cancer treatment response
This study is testing if tiny lab-grown versions of lung tumors can help doctors figure out which cancer treatments will work best for patients.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.