dTMS to reduce antipsychotic-induced weight gain in schizophrenia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial tests whether deep transcranial magnetic stimulation (dTMS) using an H4 coil can reduce weight gain associated with antipsychotic treatment in schizophrenia. It uses a randomized, single-session crossover design with sham control and a 30-person sample, including conditions with food-craving cues and without cues, to explore safety, tolerability, and efficacy. Participants undergo three sessions with washout periods, and outcomes include craving scores, subjective appetite, and behavioral measures of inhibitory control. The study also examines whether symptom provocation modulates the brain response to dTMS. Follow-ups occur at baseline and after each session.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged between 18-60
* Meeting the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic criteria for schizophrenia, confirmed by the Structured Clinical Interview for DSM-5 (SCID-5).
* Gaining body weight around 7% after intaking antipsychotics within 2 years
* Participants were on a stable medication regimen at the time of enrollment
* Written informed consent was obtained from both the participants and their legally authorized guardians

Exclusion Criteria:

* Participants who switch antipsychotic drugs (APDs) or require a dose modification exceeding 25% of the baseline dosage during the study period.
* Diagnosed with other mental diseases in accordance with DSM-V
* Comorbid with other severe physiological diseases
* Active suicidal ideation
* A history of alcohol or substance use disorder (or abuse)
* Presence of metal implants or any other conditions contraindicated for magnetic resonance imaging (MRI)
* Presence of intracranial metal or electronic devices, a personal or family history of epilepsy, or any other standard contraindications to deep transcranial magnetic stimulation
* Receipt of regular repetitive transcranial magnetic stimulation (rTMS), electroconvulsive therapy (ECT), or weight-loss interventions within the past month
* Pregnant or lactating women

Where it's running

• The Second Xiangya Hospital of Central South University
  Changsha, Hunan, China Recruiting

Study contacts

• Study coordinator: Ping Shao
• Email: shp97jw@163.com
• Phone: +86-13755112445

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.