Doxycycline to treat post-operative seromas after orthopedic surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 2 interventional study explores doxycycline sclerotherapy as a treatment for seromas that occur after orthopedic surgery. Eligible adults with imaging-confirmed seromas will receive doxycycline in an effort to induce fibrosis and eliminate the potential space. The approach aims to reduce fluid recurrence, support wound healing, and improve postoperative recovery. Outcomes will focus on seroma resolution, safety, and any impact on rehabilitation progress. The study is conducted at the University of Miami with no listed collaborators.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient with seroma formation following orthopedic procedure
* \>18 years old
* Willing and able to provide informed consent
* Pre-operative imaging (US, CT) demonstrating seroma formation

Exclusion Criteria:

* Pregnancy or lactation
* Age \<18 years
* Known allergy to tetracyclines
* Significant hepatic or renal dysfunction (Alanine Aminotransferase (ALT)/Aspartate Aminotransferase (AST) \>3× Upper Limit of Normal (ULN), Creatinine Clearance (CrCl \<30 mL/min)
* History of photosensitivity or photodermatosis
* Concurrent isotretinoin or retinoid therapy
* Current use of anticoagulants or immunosuppressants
* Active GI ulceration or esophageal disease
* Any condition likely to impair adherence or drug absorption (e.g., malabsorption syndromes)

Where it's running

• University of Miami
  Coral Gables, Florida, United States Recruiting

Study contacts

• Principal investigator: Colin McNamara, MD — University of Miami
• Study coordinator: Robert E Carrier, DO
• Email: rec182@miami.edu
• Phone: 413-478-8417

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.